Location of metastases in cancer of unknown primary are not random and signal familial clustering.
Hemminki, Kari LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Hemminki, Akseli and Ji, Jianguang LU
(2016)
In Scientific Reports
6.
- Abstract
- Cancer of unknown primary (CUP) is a fatal disease diagnosed through metastases. It shows intriguing familial clustering with certain defined primary cancers. Here we examine whether metastatic location in CUP patients is related to primary non-CUP cancers in relatives based on the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP patients defined by metastatic location depending on cancer in their first degree relatives. SIRs for CUP were high in association with liver (3.94), ovarian (3.41), lung (2.43) and colorectal cancers (1.83) in relatives. The SIR was 1.63 for CUP with metastases in the abdomen when a relative was diagnosed with ovarian cancer. CUP with liver metastases associated with liver... (More)
- Cancer of unknown primary (CUP) is a fatal disease diagnosed through metastases. It shows intriguing familial clustering with certain defined primary cancers. Here we examine whether metastatic location in CUP patients is related to primary non-CUP cancers in relatives based on the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP patients defined by metastatic location depending on cancer in their first degree relatives. SIRs for CUP were high in association with liver (3.94), ovarian (3.41), lung (2.43) and colorectal cancers (1.83) in relatives. The SIR was 1.63 for CUP with metastases in the abdomen when a relative was diagnosed with ovarian cancer. CUP with liver metastases associated with liver (1.44) cancer in relatives. CUP with head and neck region metastases associated with relatives' esophageal (2.87) cancer. CUP metastases in the thorax associated with a relative's cancers in the upper aerodigestive tract (2.14) and lung (1.74). The findings, matching metastatic location in CUP and primary cancer in relatives, could be reconciled if these cases of CUP constitute a phenotypically modified primary lacking tissue identification, resulting from epitope immunoediting. Alternatively, CUP metastases arise in a genetically favored tissue environment (soil) promoting growth of both primary cancers and metastases (seeds). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8852997
- author
- Hemminki, Kari
LU
; Sundquist, Kristina
LU
; Sundquist, Jan
LU
; Hemminki, Akseli
and Ji, Jianguang
LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 6
- article number
- 22891
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:26956545
- scopus:84960511175
- wos:000372026300001
- pmid:26956545
- ISSN
- 2045-2322
- DOI
- 10.1038/srep22891
- language
- English
- LU publication?
- yes
- id
- 64fee888-16bf-4fa4-8157-d079273c6c28 (old id 8852997)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26956545?dopt=Abstract
- date added to LUP
- 2016-04-04 09:29:48
- date last changed
- 2022-04-08 03:20:13
@article{64fee888-16bf-4fa4-8157-d079273c6c28,
abstract = {{Cancer of unknown primary (CUP) is a fatal disease diagnosed through metastases. It shows intriguing familial clustering with certain defined primary cancers. Here we examine whether metastatic location in CUP patients is related to primary non-CUP cancers in relatives based on the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP patients defined by metastatic location depending on cancer in their first degree relatives. SIRs for CUP were high in association with liver (3.94), ovarian (3.41), lung (2.43) and colorectal cancers (1.83) in relatives. The SIR was 1.63 for CUP with metastases in the abdomen when a relative was diagnosed with ovarian cancer. CUP with liver metastases associated with liver (1.44) cancer in relatives. CUP with head and neck region metastases associated with relatives' esophageal (2.87) cancer. CUP metastases in the thorax associated with a relative's cancers in the upper aerodigestive tract (2.14) and lung (1.74). The findings, matching metastatic location in CUP and primary cancer in relatives, could be reconciled if these cases of CUP constitute a phenotypically modified primary lacking tissue identification, resulting from epitope immunoediting. Alternatively, CUP metastases arise in a genetically favored tissue environment (soil) promoting growth of both primary cancers and metastases (seeds).}},
author = {{Hemminki, Kari and Sundquist, Kristina and Sundquist, Jan and Hemminki, Akseli and Ji, Jianguang}},
issn = {{2045-2322}},
language = {{eng}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{Location of metastases in cancer of unknown primary are not random and signal familial clustering.}},
url = {{http://dx.doi.org/10.1038/srep22891}},
doi = {{10.1038/srep22891}},
volume = {{6}},
year = {{2016}},
}