Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.
Fogelmark, Karl LU ; Peterson, Carsten LU and Troein, Carl LU
(2016)
In PLoS ONE
11(2).
- Abstract
- Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the connections between them. Selection determines what mutations are accepted, but its importance for shaping the resulting networks has been debated.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8857051
- author
- Fogelmark, Karl
LU
; Peterson, Carsten
LU
and Troein, Carl
LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 11
- issue
- 2
- article number
- e0150340
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:26927540
- scopus:84960404106
- wos:000371424200037
- pmid:26927540
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0150340
- language
- English
- LU publication?
- yes
- id
- 804cb3de-e831-4c9f-9823-4b2829a5b896 (old id 8857051)
- date added to LUP
- 2016-04-01 15:01:36
- date last changed
- 2022-06-17 18:29:30
@article{804cb3de-e831-4c9f-9823-4b2829a5b896,
abstract = {{Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the connections between them. Selection determines what mutations are accepted, but its importance for shaping the resulting networks has been debated.}},
author = {{Fogelmark, Karl and Peterson, Carsten and Troein, Carl}},
issn = {{1932-6203}},
language = {{eng}},
number = {{2}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.}},
url = {{http://dx.doi.org/10.1371/journal.pone.0150340}},
doi = {{10.1371/journal.pone.0150340}},
volume = {{11}},
year = {{2016}},
}