A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis
(2002) In European Journal of Clinical Pharmacology 58(4). p.275-283- Abstract
- Objective: To evaluate risk factors - notably drugs - for developing acute pancreatitis. Methods: A population-based, case-control study, encompassing 1.4 million inhabitants aged 20-85 years from four regions in Sweden between 1 January 1995 and 31 May 1998. A total of 462 cases were hospitalised in surgical departments with their first episode of acute pancreatitis without previously known biliary stone disease. From a population register, 1781 controls were randomly selected. Information was obtained from medical records and through telephone interviews. Results: Fifty-seven percent of the cases were males. An expert group found evidence for biliary stones in 50% of the cases, alcohol intake in 23%, but in 29% neither of these factors... (More)
- Objective: To evaluate risk factors - notably drugs - for developing acute pancreatitis. Methods: A population-based, case-control study, encompassing 1.4 million inhabitants aged 20-85 years from four regions in Sweden between 1 January 1995 and 31 May 1998. A total of 462 cases were hospitalised in surgical departments with their first episode of acute pancreatitis without previously known biliary stone disease. From a population register, 1781 controls were randomly selected. Information was obtained from medical records and through telephone interviews. Results: Fifty-seven percent of the cases were males. An expert group found evidence for biliary stones in 50% of the cases, alcohol intake in 23%, but in 29% neither of these factors were present. In all, "other" factors, e.g. drugs, could have contributed to the development of acute pancreatitis in 52% of the cases. In a multivariate analysis, the adjusted odds ratios (ORs) for H-2 antagonists were 2.4 (95% CI 1.2-4.8) for proton pump inhibitors (PPIs), 2.1 (1.2-3.4) for non-steroidal anti-inflammatory drugs (NSAIDs), 2.3 (1.3-4.0) for those derived from acetic acid and 1.9 (1.1-3.2) antibacterials for systemic use. Significant ORs were found for a history of gastrointestinal tract disorders [1.5 (1.1-1.9)] and inflammatory bowel disease (IBD) [3.4 (1.5-7.9)]. Smoking was significantly associated with acute pancreatitis [1.7 (1.2-2.1)] and, for those smoking more than 20 cigarettes per day, the OR was 4.0 (2.27.5). Alcohol in moderate amounts did not increase the risk, but for those drinking more than 420 g alcohol per week the OR was 4.1 (2.2-7.5). Conclusion: In addition to cholelithiasis, smoking and heavy alcohol use, drugs may be an important risk factor for acute pancreatitis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/892784
- author
- Blomgren, KB ; Sundstrom, A ; Steineck, G ; Genell, S ; Sjostedt, S and Wiholm, BE
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acute pancreatitis, risk factors, case-control study
- in
- European Journal of Clinical Pharmacology
- volume
- 58
- issue
- 4
- pages
- 275 - 283
- publisher
- Springer
- external identifiers
-
- pmid:12136374
- wos:000177241500008
- scopus:0036020412
- ISSN
- 1432-1041
- DOI
- 10.1007/s00228-002-0471-4
- language
- English
- LU publication?
- no
- id
- 16bcf48b-9e4c-4732-a476-601845eca35b (old id 892784)
- date added to LUP
- 2016-04-01 16:38:43
- date last changed
- 2022-04-15 06:00:32
@article{16bcf48b-9e4c-4732-a476-601845eca35b,
abstract = {{Objective: To evaluate risk factors - notably drugs - for developing acute pancreatitis. Methods: A population-based, case-control study, encompassing 1.4 million inhabitants aged 20-85 years from four regions in Sweden between 1 January 1995 and 31 May 1998. A total of 462 cases were hospitalised in surgical departments with their first episode of acute pancreatitis without previously known biliary stone disease. From a population register, 1781 controls were randomly selected. Information was obtained from medical records and through telephone interviews. Results: Fifty-seven percent of the cases were males. An expert group found evidence for biliary stones in 50% of the cases, alcohol intake in 23%, but in 29% neither of these factors were present. In all, "other" factors, e.g. drugs, could have contributed to the development of acute pancreatitis in 52% of the cases. In a multivariate analysis, the adjusted odds ratios (ORs) for H-2 antagonists were 2.4 (95% CI 1.2-4.8) for proton pump inhibitors (PPIs), 2.1 (1.2-3.4) for non-steroidal anti-inflammatory drugs (NSAIDs), 2.3 (1.3-4.0) for those derived from acetic acid and 1.9 (1.1-3.2) antibacterials for systemic use. Significant ORs were found for a history of gastrointestinal tract disorders [1.5 (1.1-1.9)] and inflammatory bowel disease (IBD) [3.4 (1.5-7.9)]. Smoking was significantly associated with acute pancreatitis [1.7 (1.2-2.1)] and, for those smoking more than 20 cigarettes per day, the OR was 4.0 (2.27.5). Alcohol in moderate amounts did not increase the risk, but for those drinking more than 420 g alcohol per week the OR was 4.1 (2.2-7.5). Conclusion: In addition to cholelithiasis, smoking and heavy alcohol use, drugs may be an important risk factor for acute pancreatitis.}},
author = {{Blomgren, KB and Sundstrom, A and Steineck, G and Genell, S and Sjostedt, S and Wiholm, BE}},
issn = {{1432-1041}},
keywords = {{acute pancreatitis; risk factors; case-control study}},
language = {{eng}},
number = {{4}},
pages = {{275--283}},
publisher = {{Springer}},
series = {{European Journal of Clinical Pharmacology}},
title = {{A Swedish case-control network for studies of drug-induced morbidity - acute pancreatitis}},
url = {{http://dx.doi.org/10.1007/s00228-002-0471-4}},
doi = {{10.1007/s00228-002-0471-4}},
volume = {{58}},
year = {{2002}},
}