Weight change and mortality: The Nord-Trondelag Health Study
(2005) In Journal of Internal Medicine 257(4). p.338-345- Abstract
- Objectives. The prevalence of obesity is increasing. Overweight and obese people have increased mortality compared with normal weight people. We investigated the effect of weight change on mortality. Design. Prospective population study. Setting. We utilized data from two large population-based health studies conducted in 1984-86 and 1995-97 respectively. Cox proportional hazards models were used to calculate mortality rate ratios (RRs) with 95% confidence intervals (CIs) between people with a stable weight and people who lost or gained weight. Subjects. Totally 20 542 men and 23 712 women aged 20 years or more, without cardiovascular disease or diabetes at the first survey and without a history of cancer at the second survey were followed... (More)
- Objectives. The prevalence of obesity is increasing. Overweight and obese people have increased mortality compared with normal weight people. We investigated the effect of weight change on mortality. Design. Prospective population study. Setting. We utilized data from two large population-based health studies conducted in 1984-86 and 1995-97 respectively. Cox proportional hazards models were used to calculate mortality rate ratios (RRs) with 95% confidence intervals (CIs) between people with a stable weight and people who lost or gained weight. Subjects. Totally 20 542 men and 23 712 women aged 20 years or more, without cardiovascular disease or diabetes at the first survey and without a history of cancer at the second survey were followed up on all-cause mortality for 5 years after the second survey. Results. We found no association between weight gain and mortality. People who lost weight had a higher total mortality rate compared with those who were weight stable [RR was 1.6 (95% CI: 1.4-1.8) in men and 1.7 (95% CI: 1.5-2.0) in women]. Similar associations were found for cardiovascular and noncardiovascular mortality. Additional analysis showed a linear increase in mortality rates across categories of weight loss for both men and women (P < 0.001). There was a statistically significant interaction between weight change and initial BMI, but only amongst men (P = 0.001). Conclusions. Weight loss, but not weight gain, was associated with increased mortality amongst men and women. Although underlying undiagnosed disease is the most plausible explanation for this finding, the similar associations found for total mortality, cardiovascular mortality, and noncardiovascular mortality makes the causal pathway somewhat enigmatic. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/897073
- author
- Droyvold, WB ; Nilsen, TIL ; Lydersen, S ; Midthjell, K ; Nilsson, Peter LU ; Nilsson, J and Holmen, J
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- weight change, smoking, body mass index, physical activity
- in
- Journal of Internal Medicine
- volume
- 257
- issue
- 4
- pages
- 338 - 345
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000227594000003
- pmid:15788003
- scopus:16244379203
- ISSN
- 1365-2796
- DOI
- 10.1111/j.1365-2796.2005.01458.x
- language
- English
- LU publication?
- yes
- id
- 72516fae-fabe-4575-bd49-4d5c02c8d472 (old id 897073)
- date added to LUP
- 2016-04-01 16:28:28
- date last changed
- 2022-01-28 19:56:00
@article{72516fae-fabe-4575-bd49-4d5c02c8d472,
abstract = {{Objectives. The prevalence of obesity is increasing. Overweight and obese people have increased mortality compared with normal weight people. We investigated the effect of weight change on mortality. Design. Prospective population study. Setting. We utilized data from two large population-based health studies conducted in 1984-86 and 1995-97 respectively. Cox proportional hazards models were used to calculate mortality rate ratios (RRs) with 95% confidence intervals (CIs) between people with a stable weight and people who lost or gained weight. Subjects. Totally 20 542 men and 23 712 women aged 20 years or more, without cardiovascular disease or diabetes at the first survey and without a history of cancer at the second survey were followed up on all-cause mortality for 5 years after the second survey. Results. We found no association between weight gain and mortality. People who lost weight had a higher total mortality rate compared with those who were weight stable [RR was 1.6 (95% CI: 1.4-1.8) in men and 1.7 (95% CI: 1.5-2.0) in women]. Similar associations were found for cardiovascular and noncardiovascular mortality. Additional analysis showed a linear increase in mortality rates across categories of weight loss for both men and women (P < 0.001). There was a statistically significant interaction between weight change and initial BMI, but only amongst men (P = 0.001). Conclusions. Weight loss, but not weight gain, was associated with increased mortality amongst men and women. Although underlying undiagnosed disease is the most plausible explanation for this finding, the similar associations found for total mortality, cardiovascular mortality, and noncardiovascular mortality makes the causal pathway somewhat enigmatic.}},
author = {{Droyvold, WB and Nilsen, TIL and Lydersen, S and Midthjell, K and Nilsson, Peter and Nilsson, J and Holmen, J}},
issn = {{1365-2796}},
keywords = {{weight change; smoking; body mass index; physical activity}},
language = {{eng}},
number = {{4}},
pages = {{338--345}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Weight change and mortality: The Nord-Trondelag Health Study}},
url = {{http://dx.doi.org/10.1111/j.1365-2796.2005.01458.x}},
doi = {{10.1111/j.1365-2796.2005.01458.x}},
volume = {{257}},
year = {{2005}},
}