Alignment of endocrine, anthropometric and metabolic parameters in type 2 diabetes after intervention with an Okinawan-based Nordic diet
(2018) In Food and Nutrition Research 62.- Abstract
- Background: An Okinawa-based Nordic diet with moderately low carbohydrate content and high fat and protein content has been shown to improve anthropometry and metabolism in type 2 diabetes.Objective: The objectives of this study were to measure plasma or serum levels of hormones regulating energy metabolism and metabolic control, that is, cholecystokinin (CCK), Cortisol, C-peptide, ghrelin, glucagon, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, leptin, plasminogen activator inhibitor-1 (PAI-1), polypeptide YY (PYY), resistin, and visfatin after this diet intervention, and to determine partial correlations between hormonal levels and anthropometric and metabolic responses.Design: A total of... (More)
- Background: An Okinawa-based Nordic diet with moderately low carbohydrate content and high fat and protein content has been shown to improve anthropometry and metabolism in type 2 diabetes.Objective: The objectives of this study were to measure plasma or serum levels of hormones regulating energy metabolism and metabolic control, that is, cholecystokinin (CCK), Cortisol, C-peptide, ghrelin, glucagon, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, leptin, plasminogen activator inhibitor-1 (PAI-1), polypeptide YY (PYY), resistin, and visfatin after this diet intervention, and to determine partial correlations between hormonal levels and anthropometric and metabolic responses.Design: A total of 30 patients (17 women) with type 2 diabetes, mean age 57.5 ± 8.2 years, and body mass index (BMI) 29.9 ± 4.1 kg/m2 were served the diet for 12 weeks. Fasting hormones were measured by Luminex and enzyme–linked immunosorbent assay (ELISA) before study start and after 12 and 28 weeks, along with anthropometric and metabolic parameters.Result: The levels of CCK (P = 0.005), cortisol (P = 0.015), C-peptide (P = 0.022), glucagon (P = 0.003), GLP-1 (P = 0.013), GIP (P < 0.001), insulin (P = 0.004), leptin (P < 0.001), and PYY (P < 0.001) were lowered after dietary intervention. These reduced levels only remained for PYY at week 28 (P = 0.002), when also ghrelin (P = 0.012) and visfatin (P = 0.021) levels were reduced. Changes of glucose values correlated with changed levels of C-peptide and PYY (P < 0.001), insulin (P = 0.002), and PAI-1 (P = 0.009); changes of triglyceride values with changed levels of C-peptide, insulin, and PYY (P < 0.001) and PAI-1 (P = 0.005); changes of insulin resistance with changes of leptin levels (P = 0.003); and changes of BMI values with changed levels of C-peptide, insulin, and leptin (P < 0.001).Conclusions: Okinawa-based Nordic diet in type 2 diabetes has significant impact on the endocrine profile, which correlates with anthropometric and metabolic improvements. (Less)
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https://lup.lub.lu.se/record/8d22d66b-d2f1-4ec4-8375-6393871bfa29
- author
- Ohlsson, Bodil LU ; Darwiche, Gassan LU ; Roth, Bodil LU and Höglund, Peter LU
- organization
-
- Internal Medicine - Epidemiology (research group)
- Department of Clinical Sciences, Malmö
- Clinical Coagulation, Malmö (research group)
- Gastroenterology (research group)
- Clinical studies in CKD (research group)
- Artificial Intelligence in CardioThoracic Sciences (AICTS) (research group)
- Division of Clinical Chemistry and Pharmacology
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Food and Nutrition Research
- volume
- 62
- publisher
- Co-Action Publishing
- external identifiers
-
- pmid:29599686
- scopus:85054273831
- ISSN
- 1654-661X
- DOI
- 10.29219/fnr.v62.1328
- language
- English
- LU publication?
- yes
- id
- 8d22d66b-d2f1-4ec4-8375-6393871bfa29
- date added to LUP
- 2019-06-17 12:51:04
- date last changed
- 2022-05-03 22:34:02
@article{8d22d66b-d2f1-4ec4-8375-6393871bfa29,
abstract = {{Background: An Okinawa-based Nordic diet with moderately low carbohydrate content and high fat and protein content has been shown to improve anthropometry and metabolism in type 2 diabetes.Objective: The objectives of this study were to measure plasma or serum levels of hormones regulating energy metabolism and metabolic control, that is, cholecystokinin (CCK), Cortisol, C-peptide, ghrelin, glucagon, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, leptin, plasminogen activator inhibitor-1 (PAI-1), polypeptide YY (PYY), resistin, and visfatin after this diet intervention, and to determine partial correlations between hormonal levels and anthropometric and metabolic responses.Design: A total of 30 patients (17 women) with type 2 diabetes, mean age 57.5 ± 8.2 years, and body mass index (BMI) 29.9 ± 4.1 kg/m2 were served the diet for 12 weeks. Fasting hormones were measured by Luminex and enzyme–linked immunosorbent assay (ELISA) before study start and after 12 and 28 weeks, along with anthropometric and metabolic parameters.Result: The levels of CCK (P = 0.005), cortisol (P = 0.015), C-peptide (P = 0.022), glucagon (P = 0.003), GLP-1 (P = 0.013), GIP (P < 0.001), insulin (P = 0.004), leptin (P < 0.001), and PYY (P < 0.001) were lowered after dietary intervention. These reduced levels only remained for PYY at week 28 (P = 0.002), when also ghrelin (P = 0.012) and visfatin (P = 0.021) levels were reduced. Changes of glucose values correlated with changed levels of C-peptide and PYY (P < 0.001), insulin (P = 0.002), and PAI-1 (P = 0.009); changes of triglyceride values with changed levels of C-peptide, insulin, and PYY (P < 0.001) and PAI-1 (P = 0.005); changes of insulin resistance with changes of leptin levels (P = 0.003); and changes of BMI values with changed levels of C-peptide, insulin, and leptin (P < 0.001).Conclusions: Okinawa-based Nordic diet in type 2 diabetes has significant impact on the endocrine profile, which correlates with anthropometric and metabolic improvements.}},
author = {{Ohlsson, Bodil and Darwiche, Gassan and Roth, Bodil and Höglund, Peter}},
issn = {{1654-661X}},
language = {{eng}},
publisher = {{Co-Action Publishing}},
series = {{Food and Nutrition Research}},
title = {{Alignment of endocrine, anthropometric and metabolic parameters in type 2 diabetes after intervention with an Okinawan-based Nordic diet}},
url = {{http://dx.doi.org/10.29219/fnr.v62.1328}},
doi = {{10.29219/fnr.v62.1328}},
volume = {{62}},
year = {{2018}},
}