Cystatin C modulates cerebral beta-amyloidosis
Kaeser, Stephan A. ; Herzig, Martin C. ; Coomaraswamy, Janaky ; Kilger, Ellen ; Selenica, Maj-Linda ; Winkler, David T. ; Staufenbiel, Matthias ; Levy, Efrat ; Grubb, Anders LU
and Jucker, Mathias
(2007)
In Nature Genetics
39(12).
p.1437-1439
- Abstract
- The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/968576
- author
- Kaeser, Stephan A.
; Herzig, Martin C.
; Coomaraswamy, Janaky
; Kilger, Ellen
; Selenica, Maj-Linda
; Winkler, David T.
; Staufenbiel, Matthias
; Levy, Efrat
; Grubb, Anders
LU
and Jucker, Mathias
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Genetics
- volume
- 39
- issue
- 12
- pages
- 1437 - 1439
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000251267400009
- scopus:36549085086
- ISSN
- 1546-1718
- DOI
- 10.1038/ng.2007.23
- language
- English
- LU publication?
- yes
- id
- 321157a5-f3cd-486d-93c6-92ba3f3b66b1 (old id 968576)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18026102
- http://www.hih-tuebingen.de/fileadmin/files/Presse/Dokumente/ng.2007.23.pdf
- http://www.nature.com/ng/journal/v39/n12/full/ng.2007.23.html
- date added to LUP
- 2016-04-01 16:56:48
- date last changed
- 2023-01-12 23:30:42
@article{321157a5-f3cd-486d-93c6-92ba3f3b66b1,
abstract = {{The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.}},
author = {{Kaeser, Stephan A. and Herzig, Martin C. and Coomaraswamy, Janaky and Kilger, Ellen and Selenica, Maj-Linda and Winkler, David T. and Staufenbiel, Matthias and Levy, Efrat and Grubb, Anders and Jucker, Mathias}},
issn = {{1546-1718}},
language = {{eng}},
number = {{12}},
pages = {{1437--1439}},
publisher = {{Nature Publishing Group}},
series = {{Nature Genetics}},
title = {{Cystatin C modulates cerebral beta-amyloidosis}},
url = {{http://dx.doi.org/10.1038/ng.2007.23}},
doi = {{10.1038/ng.2007.23}},
volume = {{39}},
year = {{2007}},
}