Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjogren's syndrome
(2007) In Scandinavian Journal of Rheumatology 36(5). p.394-401- Abstract
- Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjogren's syndrome ( pSS) and relate these to autonomic nervous function. Methods: Twenty consecutive pSS patients, according to the American - European Consensus Criteria ( AECC), and 30 age- and sex- matched controls from the Swedish general population registry were studied. All subjects completed a pharyngeal and oesophageal symptoms questionnaire and were examined by pharyngeal and oesophageal video radiography. In addition, the pSS patients were examined by two different autonomic nervous function tests, the deep breathing test [ calculating the expiration/ inspiration ( E/ I) ratio] and the finger skin blood flow test... (More)
- Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjogren's syndrome ( pSS) and relate these to autonomic nervous function. Methods: Twenty consecutive pSS patients, according to the American - European Consensus Criteria ( AECC), and 30 age- and sex- matched controls from the Swedish general population registry were studied. All subjects completed a pharyngeal and oesophageal symptoms questionnaire and were examined by pharyngeal and oesophageal video radiography. In addition, the pSS patients were examined by two different autonomic nervous function tests, the deep breathing test [ calculating the expiration/ inspiration ( E/ I) ratio] and the finger skin blood flow test [ the vasoconstriction ( VAC) index]. Results: pSS patients experienced significantly more dysphagia compared with controls ( 65% vs. 3%; p < 0.001). Pharyngeal ( 45% vs. 7%; p < 0.01), oesophageal ( 80% vs. 7%; p < 0.001) and gastro- oesophageal reflux symptoms ( 60% vs. 23%; p < 0.01) were also more prevalent in pSS patients compared with controls while pharyngeal ( 15% vs. 17%; p=NS) and oesophageal dysmotility ( 40% vs. 30%; p=NS) were not. Dysphagia was not associated with dysmotility but was found to be associated with a decreased E/ I ratio [ -1.05 ( -1.51 to -0.40) in patients with dysphagia vs. -0.21 ( -0.39 to 0.65) in patients without dysphagia; p < 0.01]. Conclusion: Subjective swallowing difficulties were more common in pSS patients than in controls while objective signs of pharyngeal and oesophageal dysmotility were not. Dysphagia in pSS patients does not seem to be related to video radiographical signs of dysmotility but may be related to an impaired parasympathetic function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/972390
- author
- Mandl, Thomas LU ; Ekberg, Olle LU ; Wollmer, Per LU ; Manthorpe, Rolf LU and Jacobsson, Lennart LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Rheumatology
- volume
- 36
- issue
- 5
- pages
- 394 - 401
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000250715400011
- scopus:35649026407
- ISSN
- 1502-7732
- DOI
- 10.1080/03009740701607638
- language
- English
- LU publication?
- yes
- id
- 41aa32cf-8f62-48b9-bb80-f2c7d03fb590 (old id 972390)
- date added to LUP
- 2016-04-01 11:51:54
- date last changed
- 2023-09-29 12:52:56
@article{41aa32cf-8f62-48b9-bb80-f2c7d03fb590,
abstract = {{Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjogren's syndrome ( pSS) and relate these to autonomic nervous function. Methods: Twenty consecutive pSS patients, according to the American - European Consensus Criteria ( AECC), and 30 age- and sex- matched controls from the Swedish general population registry were studied. All subjects completed a pharyngeal and oesophageal symptoms questionnaire and were examined by pharyngeal and oesophageal video radiography. In addition, the pSS patients were examined by two different autonomic nervous function tests, the deep breathing test [ calculating the expiration/ inspiration ( E/ I) ratio] and the finger skin blood flow test [ the vasoconstriction ( VAC) index]. Results: pSS patients experienced significantly more dysphagia compared with controls ( 65% vs. 3%; p < 0.001). Pharyngeal ( 45% vs. 7%; p < 0.01), oesophageal ( 80% vs. 7%; p < 0.001) and gastro- oesophageal reflux symptoms ( 60% vs. 23%; p < 0.01) were also more prevalent in pSS patients compared with controls while pharyngeal ( 15% vs. 17%; p=NS) and oesophageal dysmotility ( 40% vs. 30%; p=NS) were not. Dysphagia was not associated with dysmotility but was found to be associated with a decreased E/ I ratio [ -1.05 ( -1.51 to -0.40) in patients with dysphagia vs. -0.21 ( -0.39 to 0.65) in patients without dysphagia; p < 0.01]. Conclusion: Subjective swallowing difficulties were more common in pSS patients than in controls while objective signs of pharyngeal and oesophageal dysmotility were not. Dysphagia in pSS patients does not seem to be related to video radiographical signs of dysmotility but may be related to an impaired parasympathetic function.}},
author = {{Mandl, Thomas and Ekberg, Olle and Wollmer, Per and Manthorpe, Rolf and Jacobsson, Lennart}},
issn = {{1502-7732}},
language = {{eng}},
number = {{5}},
pages = {{394--401}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Rheumatology}},
title = {{Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjogren's syndrome}},
url = {{http://dx.doi.org/10.1080/03009740701607638}},
doi = {{10.1080/03009740701607638}},
volume = {{36}},
year = {{2007}},
}