The role of PEDF in pancreatic cancer
Ansari, Daniel LU ; Althini, Carl ; Ohlsson, Henrik ; Bauden, Monika LU
and Andersson, Roland
LU
(2019)
In Anticancer research
39(7).
p.3311-3315
- Abstract
Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis. In murine models, loss of PEDF is sufficient to induce invasive carcinoma and this phenotype is associated with large lesions characterized by poor differentiation. Lentiviral gene transfer of PEDF has resulted in decreased microvessel density and has inhibited tumor growth. Herein we review... (More)
Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis. In murine models, loss of PEDF is sufficient to induce invasive carcinoma and this phenotype is associated with large lesions characterized by poor differentiation. Lentiviral gene transfer of PEDF has resulted in decreased microvessel density and has inhibited tumor growth. Herein we review the multifunctional role of PEDF in pancreatic cancer and its therapeutic potential.
(Less)
- author
- Ansari, Daniel
LU
; Althini, Carl
; Ohlsson, Henrik
; Bauden, Monika
LU
and Andersson, Roland
LU
- organization
- publishing date
- 2019-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Angiogenesis, Autophagy, Fibrosis, Inflammation, Metastasis, Pancreatic Cancer, PEDF, Prognosis, Review, Treatment, Tumor growth
- in
- Anticancer research
- volume
- 39
- issue
- 7
- pages
- 5 pages
- publisher
- International Institute of Cancer Research
- external identifiers
-
- scopus:85068265742
- pmid:31262851
- ISSN
- 0250-7005
- DOI
- 10.21873/anticanres.13473
- language
- English
- LU publication?
- yes
- id
- a2a89086-8644-4d4a-a130-a22f39da363e
- date added to LUP
- 2019-07-10 14:17:56
- date last changed
- 2024-04-16 16:15:07
@article{a2a89086-8644-4d4a-a130-a22f39da363e,
abstract = {{<p>Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis. In murine models, loss of PEDF is sufficient to induce invasive carcinoma and this phenotype is associated with large lesions characterized by poor differentiation. Lentiviral gene transfer of PEDF has resulted in decreased microvessel density and has inhibited tumor growth. Herein we review the multifunctional role of PEDF in pancreatic cancer and its therapeutic potential.</p>}},
author = {{Ansari, Daniel and Althini, Carl and Ohlsson, Henrik and Bauden, Monika and Andersson, Roland}},
issn = {{0250-7005}},
keywords = {{Angiogenesis; Autophagy; Fibrosis; Inflammation; Metastasis; Pancreatic Cancer; PEDF; Prognosis; Review; Treatment; Tumor growth}},
language = {{eng}},
number = {{7}},
pages = {{3311--3315}},
publisher = {{International Institute of Cancer Research}},
series = {{Anticancer research}},
title = {{The role of PEDF in pancreatic cancer}},
url = {{http://dx.doi.org/10.21873/anticanres.13473}},
doi = {{10.21873/anticanres.13473}},
volume = {{39}},
year = {{2019}},
}