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A fully automatic algorithm for assessing T2* and its certainty value for accurate cardiac and liver iron load determination

Hedström, Erik LU orcid ; Heiberg, Einar LU ; Greil, Gerald F and Nagel, Eike (2013) 16th Annual SCMR Scientific Sessions In Journal of Cardiovascular Magnetic Resonance 15(Suppl 1).
Abstract
Quantification of myocardial and liver iron load has become a mainstay of guiding therapy in thalassaemia patients. However, current quantification methods are user dependent for data-point exclusion before curve fitting, and do not report the T2* certainty. Recently, an automatic inline maximum likelihood estimate (MLE) method with k-space Rician noise correction was validated against the reference standard manual truncation method. We now present a vendor-independent offline tool for fully automatic post processing and T2* quantification with certainty estimates, tested in computer simulations and patients with iron overload.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cardiovascular Magnetic Resonance
volume
15
issue
Suppl 1
article number
P141
publisher
BioMed Central (BMC)
conference name
16th Annual SCMR Scientific Sessions
conference location
San Francisco, United States
conference dates
2013-01-31 - 2013-02-03
ISSN
1097-6647
DOI
10.1186/1532-429X-15-S1-P141
language
English
LU publication?
yes
id
b2562262-26a0-4e76-8a31-4c5bf34b2a13
alternative location
http://www.jcmr-online.com/content/15/S1/P141
date added to LUP
2017-02-02 11:37:55
date last changed
2018-11-21 21:29:25
@article{b2562262-26a0-4e76-8a31-4c5bf34b2a13,
  abstract     = {{Quantification of myocardial and liver iron load has become a mainstay of guiding therapy in thalassaemia patients. However, current quantification methods are user dependent for data-point exclusion before curve fitting, and do not report the T2* certainty. Recently, an automatic inline maximum likelihood estimate (MLE) method with k-space Rician noise correction was validated against the reference standard manual truncation method. We now present a vendor-independent offline tool for fully automatic post processing and T2* quantification with certainty estimates, tested in computer simulations and patients with iron overload.}},
  author       = {{Hedström, Erik and Heiberg, Einar and Greil, Gerald F and Nagel, Eike}},
  issn         = {{1097-6647}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{Suppl 1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Cardiovascular Magnetic Resonance}},
  title        = {{A fully automatic algorithm for assessing T2* and its certainty value for accurate cardiac and liver iron load determination}},
  url          = {{http://dx.doi.org/10.1186/1532-429X-15-S1-P141}},
  doi          = {{10.1186/1532-429X-15-S1-P141}},
  volume       = {{15}},
  year         = {{2013}},
}