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Transplantation of fetal dopamine neurons in Parkinson's disease : PET [18F]6-L-fluorodopa studies in two patients with putaminal implants

Sawle, G V ; Bloomfield, P M ; Björklund, A LU orcid ; Brooks, D J ; Brundin, P LU ; Leenders, K L ; Lindvall, O LU ; Marsden, C D ; Rehncrona, S LU and Widner, H LU , et al. (1992) In Annals of Neurology 31(2). p.73-166
Abstract

Two patients with Parkinson's disease who underwent implantation of fetal mesencephalic tissue into the putamen were serially studied using positron emission tomography and [18F]6-L-fluorodopa ([18F]dopa). The uptake of [18F]dopa is related to the functional integrity of the presynaptic dopaminergic system. Preoperative studies revealed a marked decrease in putamen [18F]dopa uptake, with lesser involvement of the caudate. Two and 4 months, respectively, after operation, both patients demonstrated functional improvement, as described elsewhere. One patient was scanned 5, 8, and 13 months after the operation and the other was scanned 7 and 12 months after the operation. In both patients, [18F]dopa uptake increased within the operated... (More)

Two patients with Parkinson's disease who underwent implantation of fetal mesencephalic tissue into the putamen were serially studied using positron emission tomography and [18F]6-L-fluorodopa ([18F]dopa). The uptake of [18F]dopa is related to the functional integrity of the presynaptic dopaminergic system. Preoperative studies revealed a marked decrease in putamen [18F]dopa uptake, with lesser involvement of the caudate. Two and 4 months, respectively, after operation, both patients demonstrated functional improvement, as described elsewhere. One patient was scanned 5, 8, and 13 months after the operation and the other was scanned 7 and 12 months after the operation. In both patients, [18F]dopa uptake increased within the operated putamen despite a progressive decrease in tracer uptake in the unoperated striatal structures. We believe that this increased uptake of [18F]dopa at the implantation site represents functional integrity within a surviving neural graft. While there has been little further clinical improvement beyond the fifth postoperative month, the uptake of [18F]dopa at the operation site in both patients has progressively increased. The kinetic data provide evidence of disease progression in the unoperated striatum, which, balanced against increasing graft function, may explain why clinical improvement reached a plateau within months after surgery.

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publication status
published
subject
keywords
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Brain Tissue Transplantation, Caudate Nucleus, Dihydroxyphenylalanine, Dopamine, Fetal Tissue Transplantation, Humans, Mesencephalon, Models, Biological, Parkinson Disease, Parkinson Disease, Secondary, Putamen, Tomography, Emission-Computed, Journal Article, Research Support, Non-U.S. Gov't
in
Annals of Neurology
volume
31
issue
2
pages
73 - 166
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:1575455
  • scopus:0026533881
ISSN
0364-5134
DOI
10.1002/ana.410310207
language
English
LU publication?
yes
id
b5941c86-ad4b-4412-8141-5e62098bdbaa
date added to LUP
2017-04-19 18:31:08
date last changed
2024-01-13 19:09:55
@article{b5941c86-ad4b-4412-8141-5e62098bdbaa,
  abstract     = {{<p>Two patients with Parkinson's disease who underwent implantation of fetal mesencephalic tissue into the putamen were serially studied using positron emission tomography and [18F]6-L-fluorodopa ([18F]dopa). The uptake of [18F]dopa is related to the functional integrity of the presynaptic dopaminergic system. Preoperative studies revealed a marked decrease in putamen [18F]dopa uptake, with lesser involvement of the caudate. Two and 4 months, respectively, after operation, both patients demonstrated functional improvement, as described elsewhere. One patient was scanned 5, 8, and 13 months after the operation and the other was scanned 7 and 12 months after the operation. In both patients, [18F]dopa uptake increased within the operated putamen despite a progressive decrease in tracer uptake in the unoperated striatal structures. We believe that this increased uptake of [18F]dopa at the implantation site represents functional integrity within a surviving neural graft. While there has been little further clinical improvement beyond the fifth postoperative month, the uptake of [18F]dopa at the operation site in both patients has progressively increased. The kinetic data provide evidence of disease progression in the unoperated striatum, which, balanced against increasing graft function, may explain why clinical improvement reached a plateau within months after surgery.</p>}},
  author       = {{Sawle, G V and Bloomfield, P M and Björklund, A and Brooks, D J and Brundin, P and Leenders, K L and Lindvall, O and Marsden, C D and Rehncrona, S and Widner, H and Frackowiak, RSJ}},
  issn         = {{0364-5134}},
  keywords     = {{1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Brain Tissue Transplantation; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine; Fetal Tissue Transplantation; Humans; Mesencephalon; Models, Biological; Parkinson Disease; Parkinson Disease, Secondary; Putamen; Tomography, Emission-Computed; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{73--166}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Annals of Neurology}},
  title        = {{Transplantation of fetal dopamine neurons in Parkinson's disease : PET [18F]6-L-fluorodopa studies in two patients with putaminal implants}},
  url          = {{http://dx.doi.org/10.1002/ana.410310207}},
  doi          = {{10.1002/ana.410310207}},
  volume       = {{31}},
  year         = {{1992}},
}