Change of mammographic density predicts the risk of contralateral breast cancer--a case-control study
(2013) In Breast Cancer Research 15(4). p.1-9- Abstract
INTRODUCTION: Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).
METHODS: We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.
RESULTS: Patients who... (More)
INTRODUCTION: Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).
METHODS: We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.
RESULTS: Patients who experienced ≥10% absolute decrease in percent density had a 55% decreased odds of CBC (OR = 0.45 95% CI: 0.24 to 0.84) relative to patients who had little or no change in density from baseline to first follow-up mammogram (mean = 1.6 (SD = 0.6) years after diagnosis), whereas among those who experienced an absolute increase in percent density we could not detect any effect on the odds of CBC (OR = 0.83 95% CI: 0.24 to 2.87).
CONCLUSION: Decrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment.
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- author
- Sandberg, Maria E. C. LU ; Li, Jingmei ; Hall, Per ; Hartman, Mikael ; Dos Santos Silva, Isabel ; Humphreys, Keith LU and Czene, Kamila
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Aged, Aged, 80 and over, Breast Density, Breast Neoplasms, Case-Control Studies, Female, Follow-Up Studies, Humans, Mammary Glands, Human, Mammography, Middle Aged, Odds Ratio, Registries, Risk, Sweden, Journal Article, Research Support, Non-U.S. Gov't
- in
- Breast Cancer Research
- volume
- 15
- issue
- 4
- article number
- R57
- pages
- 1 - 9
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:84880336085
- pmid:23876209
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr3451
- language
- English
- LU publication?
- no
- id
- c82be440-ba17-4149-a91a-ae96f8c7af42
- date added to LUP
- 2017-10-16 08:57:22
- date last changed
- 2024-04-14 20:30:43
@article{c82be440-ba17-4149-a91a-ae96f8c7af42,
abstract = {{<p>INTRODUCTION: Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).</p><p>METHODS: We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.</p><p>RESULTS: Patients who experienced ≥10% absolute decrease in percent density had a 55% decreased odds of CBC (OR = 0.45 95% CI: 0.24 to 0.84) relative to patients who had little or no change in density from baseline to first follow-up mammogram (mean = 1.6 (SD = 0.6) years after diagnosis), whereas among those who experienced an absolute increase in percent density we could not detect any effect on the odds of CBC (OR = 0.83 95% CI: 0.24 to 2.87).</p><p>CONCLUSION: Decrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment.</p>}},
author = {{Sandberg, Maria E. C. and Li, Jingmei and Hall, Per and Hartman, Mikael and Dos Santos Silva, Isabel and Humphreys, Keith and Czene, Kamila}},
issn = {{1465-5411}},
keywords = {{Adult; Aged; Aged, 80 and over; Breast Density; Breast Neoplasms; Case-Control Studies; Female; Follow-Up Studies; Humans; Mammary Glands, Human; Mammography; Middle Aged; Odds Ratio; Registries; Risk; Sweden; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{4}},
pages = {{1--9}},
publisher = {{BioMed Central (BMC)}},
series = {{Breast Cancer Research}},
title = {{Change of mammographic density predicts the risk of contralateral breast cancer--a case-control study}},
url = {{http://dx.doi.org/10.1186/bcr3451}},
doi = {{10.1186/bcr3451}},
volume = {{15}},
year = {{2013}},
}