Fungal model systems and the elucidation of pathogenicity determinants
(2014) In Fungal Genetics and Biology 70. p.42-67- Abstract
- Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed... (More)
- Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed by each species and a comparative overview of key insights obtained from genomic analysis. We then consider current trends and future challenges associated with the study of fungal pathogenicity. (Less)
- Abstract (Swedish)
- Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed... (More)
- Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed by each species and a comparative overview of key insights obtained from genomic analysis. We then consider current trends and future challenges associated with the study of fungal pathogenicity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/cb0a9183-6f05-430b-b683-f65cb1174266
- author
- Wasserstrom, Lisa LU ; Lengeler, Klaus ; Oskarsson, Therese ; Walther, Andrea and Wendland, Jürgen
- organization
- publishing date
- 2014-06-25
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Fungal Genetics and Biology
- volume
- 70
- pages
- 42 - 67
- publisher
- Elsevier
- external identifiers
-
- scopus:84904917689
- ISSN
- 1087-1845
- DOI
- 10.1016/j.fgb.2014.06.011
- language
- English
- LU publication?
- yes
- id
- cb0a9183-6f05-430b-b683-f65cb1174266
- date added to LUP
- 2016-07-01 08:38:49
- date last changed
- 2022-04-24 08:33:09
@article{cb0a9183-6f05-430b-b683-f65cb1174266,
abstract = {{Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed by each species and a comparative overview of key insights obtained from genomic analysis. We then consider current trends and future challenges associated with the study of fungal pathogenicity.}},
author = {{Wasserstrom, Lisa and Lengeler, Klaus and Oskarsson, Therese and Walther, Andrea and Wendland, Jürgen}},
issn = {{1087-1845}},
language = {{eng}},
month = {{06}},
pages = {{42--67}},
publisher = {{Elsevier}},
series = {{Fungal Genetics and Biology}},
title = {{Fungal model systems and the elucidation of pathogenicity determinants}},
url = {{http://dx.doi.org/10.1016/j.fgb.2014.06.011}},
doi = {{10.1016/j.fgb.2014.06.011}},
volume = {{70}},
year = {{2014}},
}