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Pharmacokinetics of the MRI contrast agent gadobutrol in common marmoset monkeys (Callithrix jacchus)

Helms, Gunther LU orcid ; Schlumbohm, Christina ; Garea-Rodriguez, Enrique ; Dechent, Peter and Fuchs, Eberhard (2016) In Journal of Medical Primatology 45(6). p.290-296
Abstract
Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. Results: Slow injection (1.5 minutes) resulted in an elimination half-time of 26±4 minutes. After bolus injection (15 seconds), elimination was much slower (62±8 minutes) with 45%... (More)
Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. Results: Slow injection (1.5 minutes) resulted in an elimination half-time of 26±4 minutes. After bolus injection (15 seconds), elimination was much slower (62±8 minutes) with 45% larger distribution volumes. Importantly, more gadobutrol entered the cerebrospinal fluid. Conclusions: Slow injection and a latency of about 20 minutes are recommended to avoid extravasation. Application of a triple dose of gadobutrol compensates for the fast elimination in healthy marmosets. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Medical Primatology
volume
45
issue
6
pages
7 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:84978718681
  • pmid:27417149
  • wos:000387363700002
ISSN
0047-2565
DOI
10.1111/jmp.12227
project
Structural brain MRI and SPECT of common marmosets using clinical scanners
language
English
LU publication?
yes
id
cef5bfb2-9fff-4c2c-b789-4b87c16298f8
date added to LUP
2016-08-09 10:55:23
date last changed
2022-04-24 08:59:51
@article{cef5bfb2-9fff-4c2c-b789-4b87c16298f8,
  abstract     = {{Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. Results: Slow injection (1.5 minutes) resulted in an elimination half-time of 26±4 minutes. After bolus injection (15 seconds), elimination was much slower (62±8 minutes) with 45% larger distribution volumes. Importantly, more gadobutrol entered the cerebrospinal fluid. Conclusions: Slow injection and a latency of about 20 minutes are recommended to avoid extravasation. Application of a triple dose of gadobutrol compensates for the fast elimination in healthy marmosets.}},
  author       = {{Helms, Gunther and Schlumbohm, Christina and Garea-Rodriguez, Enrique and Dechent, Peter and Fuchs, Eberhard}},
  issn         = {{0047-2565}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{6}},
  pages        = {{290--296}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Journal of Medical Primatology}},
  title        = {{Pharmacokinetics of the MRI contrast agent gadobutrol in common marmoset monkeys (Callithrix jacchus)}},
  url          = {{http://dx.doi.org/10.1111/jmp.12227}},
  doi          = {{10.1111/jmp.12227}},
  volume       = {{45}},
  year         = {{2016}},
}