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Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors

Wassélius, Johan LU ; Larsson, Stig LU ; Sundin, Anders and Jacobsson, Hans (2009) In International Journal of Cardiovascular Imaging 25(2). p.40-133
Abstract

PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.

METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.

RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90... (More)

PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.

METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.

RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years.

CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Age Factors, Aged, Aged, 80 and over, Atherosclerosis, Cardiovascular Diseases, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Positron-Emission Tomography, Radiographic Image Interpretation, Computer-Assisted, Radiopharmaceuticals, Risk Factors, Tomography, X-Ray Computed, Journal Article, Research Support, Non-U.S. Gov't
in
International Journal of Cardiovascular Imaging
volume
25
issue
2
pages
8 pages
publisher
Springer
external identifiers
  • scopus:59149090701
  • pmid:18784986
ISSN
1875-8312
DOI
10.1007/s10554-008-9366-5
language
English
LU publication?
no
id
d2f8a288-522c-40a9-b59b-77cf23a5906a
date added to LUP
2016-10-14 09:58:21
date last changed
2024-01-04 14:20:32
@article{d2f8a288-522c-40a9-b59b-77cf23a5906a,
  abstract     = {{<p>PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.</p><p>METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.</p><p>RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years.</p><p>CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.</p>}},
  author       = {{Wassélius, Johan and Larsson, Stig and Sundin, Anders and Jacobsson, Hans}},
  issn         = {{1875-8312}},
  keywords     = {{Adult; Age Factors; Aged; Aged, 80 and over; Atherosclerosis; Cardiovascular Diseases; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Risk Factors; Tomography, X-Ray Computed; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{40--133}},
  publisher    = {{Springer}},
  series       = {{International Journal of Cardiovascular Imaging}},
  title        = {{Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors}},
  url          = {{http://dx.doi.org/10.1007/s10554-008-9366-5}},
  doi          = {{10.1007/s10554-008-9366-5}},
  volume       = {{25}},
  year         = {{2009}},
}