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Familial hypercholesterolaemia : cholesterol efflux and coronary disease

Versmissen, Jorie ; Vongpromek, Ranitha ; Yahya, Reyhana ; van der Net, Jeroen B. ; van Vark-van der Zee, Leonie ; Blommesteijn-Touw, Jeannette ; Wattimena, Darcos ; Rietveld, Trinet ; Pullinger, Clive R. and Christoffersen, Christina , et al. (2016) In European Journal of Clinical Investigation 46(7). p.643-650
Abstract

Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the... (More)

Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers. Conclusions: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apolipoprotein M, cholesterol efflux, familial hypercholesterolaemia, high-density lipoprotein, sphingolipids, sphingosine-phosphate
in
European Journal of Clinical Investigation
volume
46
issue
7
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:27208892
  • scopus:84976595523
ISSN
0014-2972
DOI
10.1111/eci.12643
language
English
LU publication?
yes
id
dbc53fbe-68cf-454c-bd3a-e7aa5f5095ae
date added to LUP
2017-01-24 12:40:10
date last changed
2024-02-19 15:43:56
@article{dbc53fbe-68cf-454c-bd3a-e7aa5f5095ae,
  abstract     = {{<p>Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers. Conclusions: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.</p>}},
  author       = {{Versmissen, Jorie and Vongpromek, Ranitha and Yahya, Reyhana and van der Net, Jeroen B. and van Vark-van der Zee, Leonie and Blommesteijn-Touw, Jeannette and Wattimena, Darcos and Rietveld, Trinet and Pullinger, Clive R. and Christoffersen, Christina and Dahlbäck, Björn and Kane, John P. and Mulder, Monique and Sijbrands, Eric J G}},
  issn         = {{0014-2972}},
  keywords     = {{Apolipoprotein M; cholesterol efflux; familial hypercholesterolaemia; high-density lipoprotein; sphingolipids; sphingosine-phosphate}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{643--650}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Clinical Investigation}},
  title        = {{Familial hypercholesterolaemia : cholesterol efflux and coronary disease}},
  url          = {{http://dx.doi.org/10.1111/eci.12643}},
  doi          = {{10.1111/eci.12643}},
  volume       = {{46}},
  year         = {{2016}},
}