Autoimmunity of diabetes
Lernmark, A. LU
; Barmeier, H.
; Dube, S.
; Hagopian, W.
; Karlsen, A.
and Wassmuth, R.
(1991)
In Endocrinology and Metabolism Clinics of North America
20(3).
- Abstract
Mechanisms underlying the etiology and pathogenesis of insulin-dependent diabetes mellitus (IDDM) are reviewed. Its natural history and associated autoimmune phenomena indicate that IDDM is a systemic disorder resulting in a specific disappearance of pancreatic β cells. Genetic aspects of the disorder include its linkage to HLA class II gene loci, although the manner in which this produces autoimmunity is unclear, and a second gene outside the HLA complex could be more important. The roles of environmental influences, including viruses, also require clarification. Further studies on the molecular biology of the immune response against β cell specific antigens are required.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/dd23c1c0-9ff5-4814-a0e7-445c06dcc9dd
- author
- Lernmark, A.
LU
; Barmeier, H.
; Dube, S.
; Hagopian, W.
; Karlsen, A.
and Wassmuth, R.
- publishing date
- 1991-09-30
- type
- Contribution to journal
- publication status
- published
- in
- Endocrinology and Metabolism Clinics of North America
- volume
- 20
- issue
- 3
- publisher
- W.B. Saunders
- external identifiers
-
- pmid:1935920
- scopus:0025741818
- ISSN
- 0889-8529
- DOI
- 10.1016/S0889-8529(18)30260-3
- language
- English
- LU publication?
- no
- id
- dd23c1c0-9ff5-4814-a0e7-445c06dcc9dd
- date added to LUP
- 2019-09-11 09:40:55
- date last changed
- 2024-03-13 08:24:16
@article{dd23c1c0-9ff5-4814-a0e7-445c06dcc9dd,
abstract = {{<p>Mechanisms underlying the etiology and pathogenesis of insulin-dependent diabetes mellitus (IDDM) are reviewed. Its natural history and associated autoimmune phenomena indicate that IDDM is a systemic disorder resulting in a specific disappearance of pancreatic β cells. Genetic aspects of the disorder include its linkage to HLA class II gene loci, although the manner in which this produces autoimmunity is unclear, and a second gene outside the HLA complex could be more important. The roles of environmental influences, including viruses, also require clarification. Further studies on the molecular biology of the immune response against β cell specific antigens are required.</p>}},
author = {{Lernmark, A. and Barmeier, H. and Dube, S. and Hagopian, W. and Karlsen, A. and Wassmuth, R.}},
issn = {{0889-8529}},
language = {{eng}},
month = {{09}},
number = {{3}},
publisher = {{W.B. Saunders}},
series = {{Endocrinology and Metabolism Clinics of North America}},
title = {{Autoimmunity of diabetes}},
url = {{http://dx.doi.org/10.1016/S0889-8529(18)30260-3}},
doi = {{10.1016/S0889-8529(18)30260-3}},
volume = {{20}},
year = {{1991}},
}