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High serum total cholesterol is associated with suicide mortality in Japanese women

Svensson, T LU ; Inoue, Manami ; Sawada, Norie ; Charvat, Hadrien ; Mimura, Masaru and Tsugane, Shoichiro (2017) In Acta Psychiatrica Scandinavica 136(3). p.259-268
Abstract

OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.

METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.

RESULTS: There were 185 suicides (men: 107;... (More)

OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.

METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.

RESULTS: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men.

CONCLUSION: High TC levels may be associated with an increased risk of suicide in women.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Psychiatrica Scandinavica
volume
136
issue
3
pages
259 - 268
publisher
Wiley-Blackwell
external identifiers
  • pmid:28547796
  • scopus:85019752758
  • wos:000407010600004
ISSN
1600-0447
DOI
10.1111/acps.12758
language
English
LU publication?
yes
id
dfe241c8-368e-4b06-b875-bfeee4d5d0f7
date added to LUP
2017-05-27 23:24:26
date last changed
2024-04-14 12:13:07
@article{dfe241c8-368e-4b06-b875-bfeee4d5d0f7,
  abstract     = {{<p>OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.</p><p>METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (&lt;4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.</p><p>RESULTS: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men.</p><p>CONCLUSION: High TC levels may be associated with an increased risk of suicide in women.</p>}},
  author       = {{Svensson, T and Inoue, Manami and Sawada, Norie and Charvat, Hadrien and Mimura, Masaru and Tsugane, Shoichiro}},
  issn         = {{1600-0447}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{3}},
  pages        = {{259--268}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Psychiatrica Scandinavica}},
  title        = {{High serum total cholesterol is associated with suicide mortality in Japanese women}},
  url          = {{http://dx.doi.org/10.1111/acps.12758}},
  doi          = {{10.1111/acps.12758}},
  volume       = {{136}},
  year         = {{2017}},
}