Host–pathogen interactions of nontypeable Haemophilus influenzae : from commensal to pathogen
Duell, Ben LU ; Su, Yu Ching LU and Riesbeck, Kristian LU
(2016)
In FEBS Letters
590(21).
p.3840-3853
- Abstract
Nontypeable Haemophilus influenzae (NTHi) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against H. influenzae serotype b in the 1990s, the burden of H. influenzae-related infections has been increasingly dominated by NTHi. Understanding the ability of NTHi to cause infection is currently an expanding area of study. NTHi is able to exert differential binding to the host tissue through the use of a broad range of adhesins. NTHi survival in the host is... (More)
Nontypeable Haemophilus influenzae (NTHi) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against H. influenzae serotype b in the 1990s, the burden of H. influenzae-related infections has been increasingly dominated by NTHi. Understanding the ability of NTHi to cause infection is currently an expanding area of study. NTHi is able to exert differential binding to the host tissue through the use of a broad range of adhesins. NTHi survival in the host is multifaceted, that is, using virulence factors involved in complement resistance, biofilm, modified immunoglobulin responses, and, finally, formation and utilization of host proteins as a secondary strategy of increasing the adhesive ability.
(Less)
- author
- Duell, Ben
LU
; Su, Yu Ching
LU
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2016-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adhesion, biofilm formation, extracellular matrix, Haemophilus, intracellular, serum resistance
- in
- FEBS Letters
- volume
- 590
- issue
- 21
- pages
- 14 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:84992154186
- pmid:27508518
- wos:000387760500009
- ISSN
- 0014-5793
- DOI
- 10.1002/1873-3468.12351
- language
- English
- LU publication?
- yes
- id
- e0578d30-9fd1-45b4-9b04-ae3d7d64819b
- date added to LUP
- 2016-12-05 09:17:09
- date last changed
- 2024-04-05 11:47:35
@article{e0578d30-9fd1-45b4-9b04-ae3d7d64819b,
abstract = {{<p>Nontypeable Haemophilus influenzae (NTHi) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against H. influenzae serotype b in the 1990s, the burden of H. influenzae-related infections has been increasingly dominated by NTHi. Understanding the ability of NTHi to cause infection is currently an expanding area of study. NTHi is able to exert differential binding to the host tissue through the use of a broad range of adhesins. NTHi survival in the host is multifaceted, that is, using virulence factors involved in complement resistance, biofilm, modified immunoglobulin responses, and, finally, formation and utilization of host proteins as a secondary strategy of increasing the adhesive ability.</p>}},
author = {{Duell, Ben and Su, Yu Ching and Riesbeck, Kristian}},
issn = {{0014-5793}},
keywords = {{adhesion; biofilm formation; extracellular matrix; Haemophilus; intracellular; serum resistance}},
language = {{eng}},
month = {{11}},
number = {{21}},
pages = {{3840--3853}},
publisher = {{Wiley-Blackwell}},
series = {{FEBS Letters}},
title = {{Host–pathogen interactions of nontypeable Haemophilus influenzae : from commensal to pathogen}},
url = {{http://dx.doi.org/10.1002/1873-3468.12351}},
doi = {{10.1002/1873-3468.12351}},
volume = {{590}},
year = {{2016}},
}