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Predictive and prognostic clinical variables in cancer patients treated with adenoviral oncolytic immunotherapy

Taipale, K ; Liikanen, I ; Koski, A ; Heiskanen, R ; Kanerva, A ; Hemminki, O ; Oksanen, M ; Grönberg-Vähä-Koskela, S ; Hemminki, K LU and Joensuu, T , et al. (2016) In Molecular Therapy 24(7). p.1323-1332
Abstract

The development of oncolytic viruses has recently made great progress towards being available to cancer patients. With the breakthrough into clinics, it is crucial to analyze the existing clinical experience and use it as a basis for treatment improvements. Here we report clinical data from 290 patients treated with oncolytic adenovirus. Using clinical variables and treatment characteristics, we constructed statistical models with regard to treatment response and overall survival. Additionally, we investigated effects of neutralizing antibodies, tumor burden and peripheral blood leucocyte counts on these outcomes. We found the absence of liver metastases to correlate with an improved rate of disease control (p=0.021). In multivariate... (More)

The development of oncolytic viruses has recently made great progress towards being available to cancer patients. With the breakthrough into clinics, it is crucial to analyze the existing clinical experience and use it as a basis for treatment improvements. Here we report clinical data from 290 patients treated with oncolytic adenovirus. Using clinical variables and treatment characteristics, we constructed statistical models with regard to treatment response and overall survival. Additionally, we investigated effects of neutralizing antibodies, tumor burden and peripheral blood leucocyte counts on these outcomes. We found the absence of liver metastases to correlate with an improved rate of disease control (p=0.021). In multivariate evaluation, patients treated with viruses coding for immunostimulatory granulocyte macrophage colony-stimulating factor were linked to better prognosis (HR 0.378, p<0.001), as well as women with any cancer type (HR 0.694, p=0.017). In multivariate analysis for imaging response, patients treated via intraperitoneal injection were more likely to achieve disease control (OR 3.246, p=0.027). Patients with low neutrophil-to-lymphocyte ratio before treatment, had significantly longer overall survival (p<0.001). These findings could explain some of the variation seen in treatment outcomes after virotherapy. Furthermore, the results offer hypotheses for treatment optimization and patient selection in oncolytic adenovirus immunotherapy.Molecular Therapy (2016); doi:10.1038/mt.2016.67.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Therapy
volume
24
issue
7
pages
1323 - 1332
publisher
Nature Publishing Group
external identifiers
  • pmid:27039846
  • scopus:84965010332
  • wos:000381418300018
ISSN
1525-0024
DOI
10.1038/mt.2016.67
language
English
LU publication?
yes
id
ed877298-9bcf-44ae-961a-e40f9c499cd2
date added to LUP
2016-04-28 11:10:56
date last changed
2024-04-04 18:01:28
@article{ed877298-9bcf-44ae-961a-e40f9c499cd2,
  abstract     = {{<p>The development of oncolytic viruses has recently made great progress towards being available to cancer patients. With the breakthrough into clinics, it is crucial to analyze the existing clinical experience and use it as a basis for treatment improvements. Here we report clinical data from 290 patients treated with oncolytic adenovirus. Using clinical variables and treatment characteristics, we constructed statistical models with regard to treatment response and overall survival. Additionally, we investigated effects of neutralizing antibodies, tumor burden and peripheral blood leucocyte counts on these outcomes. We found the absence of liver metastases to correlate with an improved rate of disease control (p=0.021). In multivariate evaluation, patients treated with viruses coding for immunostimulatory granulocyte macrophage colony-stimulating factor were linked to better prognosis (HR 0.378, p&lt;0.001), as well as women with any cancer type (HR 0.694, p=0.017). In multivariate analysis for imaging response, patients treated via intraperitoneal injection were more likely to achieve disease control (OR 3.246, p=0.027). Patients with low neutrophil-to-lymphocyte ratio before treatment, had significantly longer overall survival (p&lt;0.001). These findings could explain some of the variation seen in treatment outcomes after virotherapy. Furthermore, the results offer hypotheses for treatment optimization and patient selection in oncolytic adenovirus immunotherapy.Molecular Therapy (2016); doi:10.1038/mt.2016.67.</p>}},
  author       = {{Taipale, K and Liikanen, I and Koski, A and Heiskanen, R and Kanerva, A and Hemminki, O and Oksanen, M and Grönberg-Vähä-Koskela, S and Hemminki, K and Joensuu, T and Hemminki, A}},
  issn         = {{1525-0024}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1323--1332}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Molecular Therapy}},
  title        = {{Predictive and prognostic clinical variables in cancer patients treated with adenoviral oncolytic immunotherapy}},
  url          = {{http://dx.doi.org/10.1038/mt.2016.67}},
  doi          = {{10.1038/mt.2016.67}},
  volume       = {{24}},
  year         = {{2016}},
}