Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease
(2015) In PLoS Currents 7.- Abstract
BACKGROUND: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.
METHODS: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.
RESULTS: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.
CONCLUSION: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a... (More)
BACKGROUND: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.
METHODS: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.
RESULTS: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.
CONCLUSION: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies.
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- author
- Collins, Lucy M ; Begeti, Faye ; Panin, Francesca ; Lazar, Alpar S ; Cruickshank, Travis ; Ziman, Mel ; Mason, Sarah L and Barker, Roger A LU
- organization
- publishing date
- 2015-09-08
- type
- Contribution to journal
- publication status
- published
- keywords
- Journal Article
- in
- PLoS Currents
- volume
- 7
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:26421223
- scopus:84958559094
- ISSN
- 2157-3999
- DOI
- 10.1371/currents.hd.ded251617ae62a1364506b0521bd3761
- language
- English
- LU publication?
- no
- id
- f79ae46a-ade3-4f2b-a276-20ad3f6b968c
- date added to LUP
- 2016-11-23 13:26:58
- date last changed
- 2024-01-04 17:02:55
@article{f79ae46a-ade3-4f2b-a276-20ad3f6b968c, abstract = {{<p>BACKGROUND: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.</p><p>METHODS: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.</p><p>RESULTS: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.</p><p>CONCLUSION: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies.</p>}}, author = {{Collins, Lucy M and Begeti, Faye and Panin, Francesca and Lazar, Alpar S and Cruickshank, Travis and Ziman, Mel and Mason, Sarah L and Barker, Roger A}}, issn = {{2157-3999}}, keywords = {{Journal Article}}, language = {{eng}}, month = {{09}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS Currents}}, title = {{Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease}}, url = {{http://dx.doi.org/10.1371/currents.hd.ded251617ae62a1364506b0521bd3761}}, doi = {{10.1371/currents.hd.ded251617ae62a1364506b0521bd3761}}, volume = {{7}}, year = {{2015}}, }