Assessment of increasing intravenous adenosine dose in fractional flow reserve
Sparv, David LU ; Götberg, Matthias LU ; Harnek, Jan LU ; Persson, Tobias ; Madsen-Härdig, Bjarne LU and Erlinge, David LU
(2017)
In BMC Cardiovascular Disorders
17(1).
p.1-9
- Abstract
Background: Effects of increased adenosine dose in the assessment of fractional flow reserve (FFR) were studied in relation to FFR results, hemodynamic effects and patient discomfort. FFR require maximal hyperemia mediated by adenosine. Standard dose is 140 μg/kg/min administrated intravenously. Higher doses are commonly used in clinical practice, but an extensive comparison between standard intravenous dose and a high dose (220 μg/kg/min) has previously not been performed. Methods: Seventy-five patients undergoing FFR received standard dose adenosine, followed by high dose adenosine. FFR, mean arterial pressure (MAP) and heart rate (HR) were analyzed. Patient discomfort measured by Visual Analogue Scale (VAS) was assessed. Results: No... (More)
Background: Effects of increased adenosine dose in the assessment of fractional flow reserve (FFR) were studied in relation to FFR results, hemodynamic effects and patient discomfort. FFR require maximal hyperemia mediated by adenosine. Standard dose is 140 μg/kg/min administrated intravenously. Higher doses are commonly used in clinical practice, but an extensive comparison between standard intravenous dose and a high dose (220 μg/kg/min) has previously not been performed. Methods: Seventy-five patients undergoing FFR received standard dose adenosine, followed by high dose adenosine. FFR, mean arterial pressure (MAP) and heart rate (HR) were analyzed. Patient discomfort measured by Visual Analogue Scale (VAS) was assessed. Results: No significant difference was found between the doses in FFR value (0.85 [0.79-0.90] vs 0.85 [0.79-0.89], p = 0.24). The two doses correlated well irrespective of lesion severity (r = 0.86, slope = 0.89, p = <0.001). There were no differences in MAP or HR. Patient discomfort was more pronounced using high dose adenosine (8.0 [5.0-9.0]) versus standard dose (5.0 [2.0-7.0]), p = <0.001. Conclusions: Increased dose adenosine does not improve hyperemia and is associated with increased patient discomfort. Our findings do not support the use of high dose adenosine. Trial registration: Retrospective Trial registration: Current Controlled Trials ISRCTN14618196. Registered 15 December 2016.
(Less)
- author
- Sparv, David
LU
; Götberg, Matthias
LU
; Harnek, Jan
LU
; Persson, Tobias
; Madsen-Härdig, Bjarne
LU
and Erlinge, David
LU
- organization
- publishing date
- 2017-02-14
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adenosine, Coronary heart disease, Fractional flow reserve, Visual analogue scale
- in
- BMC Cardiovascular Disorders
- volume
- 17
- issue
- 1
- article number
- 60
- pages
- 1 - 9
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:28196527
- wos:000410197100001
- scopus:85012882155
- ISSN
- 1471-2261
- DOI
- 10.1186/s12872-016-0463-4
- language
- English
- LU publication?
- yes
- id
- f8a82e36-fd6a-4731-91f4-e0be95d4373e
- date added to LUP
- 2017-02-27 12:44:52
- date last changed
- 2024-04-14 06:00:35
@article{f8a82e36-fd6a-4731-91f4-e0be95d4373e,
abstract = {{<p>Background: Effects of increased adenosine dose in the assessment of fractional flow reserve (FFR) were studied in relation to FFR results, hemodynamic effects and patient discomfort. FFR require maximal hyperemia mediated by adenosine. Standard dose is 140 μg/kg/min administrated intravenously. Higher doses are commonly used in clinical practice, but an extensive comparison between standard intravenous dose and a high dose (220 μg/kg/min) has previously not been performed. Methods: Seventy-five patients undergoing FFR received standard dose adenosine, followed by high dose adenosine. FFR, mean arterial pressure (MAP) and heart rate (HR) were analyzed. Patient discomfort measured by Visual Analogue Scale (VAS) was assessed. Results: No significant difference was found between the doses in FFR value (0.85 [0.79-0.90] vs 0.85 [0.79-0.89], p = 0.24). The two doses correlated well irrespective of lesion severity (r = 0.86, slope = 0.89, p = <0.001). There were no differences in MAP or HR. Patient discomfort was more pronounced using high dose adenosine (8.0 [5.0-9.0]) versus standard dose (5.0 [2.0-7.0]), p = <0.001. Conclusions: Increased dose adenosine does not improve hyperemia and is associated with increased patient discomfort. Our findings do not support the use of high dose adenosine. Trial registration: Retrospective Trial registration: Current Controlled Trials ISRCTN14618196. Registered 15 December 2016.</p>}},
author = {{Sparv, David and Götberg, Matthias and Harnek, Jan and Persson, Tobias and Madsen-Härdig, Bjarne and Erlinge, David}},
issn = {{1471-2261}},
keywords = {{Adenosine; Coronary heart disease; Fractional flow reserve; Visual analogue scale}},
language = {{eng}},
month = {{02}},
number = {{1}},
pages = {{1--9}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Cardiovascular Disorders}},
title = {{Assessment of increasing intravenous adenosine dose in fractional flow reserve}},
url = {{http://dx.doi.org/10.1186/s12872-016-0463-4}},
doi = {{10.1186/s12872-016-0463-4}},
volume = {{17}},
year = {{2017}},
}