Full-field electroretinography in age-related macular degeneration : an overall retinal response
(2021) In Acta Ophthalmologica 99(2).- Abstract
Purpose: Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG response in eyes with AMD. Methods: We performed full-field electroretinography (RETI-port/scan 21, Roland, Berlin) in 13 patients with early AMD, 25 patients with late AMD and 24 individuals without vitreoretinal disease as a control group. Dawson–Trick–Litzkow fibre electrodes were used. Statistical analysis was performed and a p-value... (More)
Purpose: Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG response in eyes with AMD. Methods: We performed full-field electroretinography (RETI-port/scan 21, Roland, Berlin) in 13 patients with early AMD, 25 patients with late AMD and 24 individuals without vitreoretinal disease as a control group. Dawson–Trick–Litzkow fibre electrodes were used. Statistical analysis was performed and a p-value <0.05 was considered significant. Results: After adjusting for multiple comparisons, both the light-adapted 3.0 a-wave implicit time (p < 0.001) and 30-Hertz flicker peak time (p = 0.012) showed significant difference between patients with late AMD and individuals without vitreoretinal disease. There was a significant difference in the light-adapted 3.0 a-wave implicit time (p = 0.011) between patients with early AMD and the control group, but the difference in 30 Hz flicker peak time was not significant (p = 0.256). Conclusion: The difference in cone function measured by light-adapted 3.0 a-wave implicit time and 30-Hertz flicker peak time in early and late AMD when compared to healthy controls suggests a more diminished overall response when AMD has reached later stages.
(Less)
- author
- Forshaw, Thomas Richard Johansen ; Kjær, Troels Wesenberg ; Andréasson, Sten LU and Sørensen, Torben Lykke
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- age-related macular degeneration, full-field electroretinography, functional testing, peripheral retina
- in
- Acta Ophthalmologica
- volume
- 99
- issue
- 2
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85089733787
- pmid:32833310
- ISSN
- 1755-375X
- DOI
- 10.1111/aos.14571
- language
- English
- LU publication?
- no
- id
- fd7bbb1c-a496-4a61-be8e-05526e5a3dc3
- date added to LUP
- 2020-09-09 16:55:08
- date last changed
- 2024-04-17 15:05:58
@article{fd7bbb1c-a496-4a61-be8e-05526e5a3dc3,
abstract = {{<p>Purpose: Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG response in eyes with AMD. Methods: We performed full-field electroretinography (RETI-port/scan 21, Roland, Berlin) in 13 patients with early AMD, 25 patients with late AMD and 24 individuals without vitreoretinal disease as a control group. Dawson–Trick–Litzkow fibre electrodes were used. Statistical analysis was performed and a p-value <0.05 was considered significant. Results: After adjusting for multiple comparisons, both the light-adapted 3.0 a-wave implicit time (p < 0.001) and 30-Hertz flicker peak time (p = 0.012) showed significant difference between patients with late AMD and individuals without vitreoretinal disease. There was a significant difference in the light-adapted 3.0 a-wave implicit time (p = 0.011) between patients with early AMD and the control group, but the difference in 30 Hz flicker peak time was not significant (p = 0.256). Conclusion: The difference in cone function measured by light-adapted 3.0 a-wave implicit time and 30-Hertz flicker peak time in early and late AMD when compared to healthy controls suggests a more diminished overall response when AMD has reached later stages.</p>}},
author = {{Forshaw, Thomas Richard Johansen and Kjær, Troels Wesenberg and Andréasson, Sten and Sørensen, Torben Lykke}},
issn = {{1755-375X}},
keywords = {{age-related macular degeneration; full-field electroretinography; functional testing; peripheral retina}},
language = {{eng}},
number = {{2}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Ophthalmologica}},
title = {{Full-field electroretinography in age-related macular degeneration : an overall retinal response}},
url = {{http://dx.doi.org/10.1111/aos.14571}},
doi = {{10.1111/aos.14571}},
volume = {{99}},
year = {{2021}},
}