Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Neurones and glial cells of the mouse sciatic nerve undergo apoptosis after injury in Vivo and in Vitro

Ekström, Per LU (1995) In NeuroReport 6(7). p.1029-1032
Abstract

Analogous to the death of developing neurones deprived of trophic factors, nerve injury in adult life could lead to nerve cell death by apoptosis. Here the occurrence of apoptotic mouse sciatic sensory neurones after injury was investigated by nick-labelling DNA breaks. A small proportion of the neurones reliably became apoptotic after injury in vivo. The response was strongly amplified when the nerves were injured in vitro, where Ca2+-chelation and protein synthesis inhibition were effective in inhibiting apoptosis. In addition to nerve cells, both Schwann cells and satellite cells became apoptotic after injury. Apoptosis in cultured mouse sciatic nerves appears advantageous for the identification of survival factors acting... (More)

Analogous to the death of developing neurones deprived of trophic factors, nerve injury in adult life could lead to nerve cell death by apoptosis. Here the occurrence of apoptotic mouse sciatic sensory neurones after injury was investigated by nick-labelling DNA breaks. A small proportion of the neurones reliably became apoptotic after injury in vivo. The response was strongly amplified when the nerves were injured in vitro, where Ca2+-chelation and protein synthesis inhibition were effective in inhibiting apoptosis. In addition to nerve cells, both Schwann cells and satellite cells became apoptotic after injury. Apoptosis in cultured mouse sciatic nerves appears advantageous for the identification of survival factors acting on adult peripheral neurones.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apoptosis, Mammalian, Nerve regeneration, Peripheral nerve, Programmed cell death, Schwann cell proliferation
in
NeuroReport
volume
6
issue
7
pages
1029 - 1032
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0029039160
  • pmid:7632888
ISSN
0959-4965
language
English
LU publication?
no
id
0886ae3e-c728-4f94-9edd-71ede32da36f
date added to LUP
2016-12-07 14:49:24
date last changed
2024-01-04 18:23:23
@article{0886ae3e-c728-4f94-9edd-71ede32da36f,
  abstract     = {{<p>Analogous to the death of developing neurones deprived of trophic factors, nerve injury in adult life could lead to nerve cell death by apoptosis. Here the occurrence of apoptotic mouse sciatic sensory neurones after injury was investigated by nick-labelling DNA breaks. A small proportion of the neurones reliably became apoptotic after injury in vivo. The response was strongly amplified when the nerves were injured in vitro, where Ca<sup>2+</sup>-chelation and protein synthesis inhibition were effective in inhibiting apoptosis. In addition to nerve cells, both Schwann cells and satellite cells became apoptotic after injury. Apoptosis in cultured mouse sciatic nerves appears advantageous for the identification of survival factors acting on adult peripheral neurones.</p>}},
  author       = {{Ekström, Per}},
  issn         = {{0959-4965}},
  keywords     = {{Apoptosis; Mammalian; Nerve regeneration; Peripheral nerve; Programmed cell death; Schwann cell proliferation}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1029--1032}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{NeuroReport}},
  title        = {{Neurones and glial cells of the mouse sciatic nerve undergo apoptosis after injury in Vivo and in Vitro}},
  volume       = {{6}},
  year         = {{1995}},
}