Advanced

The QUASAR reproducibility study, Part II : Results from a multi-center Arterial Spin Labeling test-retest study

Petersen, Esben Thade; Mouridsen, Kim; Golay, Xavier and , (2010) In NeuroImage 49(1). p.13-104
Abstract

Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across... (More)

Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across sites from around the world, dubbed "The QUASAR reproducibility study". Altogether, 28 sites located in Asia, Europe and North America participated and a total of 284 healthy volunteers were scanned. Minimal operator dependence was assured by using an automatic planning tool and its accuracy and potential usefulness in multi-center trials was evaluated as well. Accurate repositioning between sessions was achieved with the automatic planning tool showing mean displacements of 1.87+/-0.95 mm and rotations of 1.56+/-0.66 degrees . Mean gray matter CBF was 47.4+/-7.5 [ml/100 g/min] with a between-subject standard variation SD(b)=5.5 [ml/100 g/min] and a within-subject standard deviation SD(w)=4.7 [ml/100 g/min]. The corresponding repeatability was 13.0 [ml/100 g/min] and was found to be within the range of previous studies.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Adolescent, Adult, Aged, Blood Volume, Brain Mapping, Cerebral Arteries, Cerebrovascular Circulation, Female, Humans, Male, Middle Aged, Reproducibility of Results, Software, Spin Labels, Young Adult
in
NeuroImage
volume
49
issue
1
pages
10 pages
publisher
Elsevier
external identifiers
  • Scopus:70349966233
ISSN
1095-9572
DOI
10.1016/j.neuroimage.2009.07.068
language
English
LU publication?
no
id
02636649-dbda-41a0-b39c-fb8bea001b99
date added to LUP
2016-09-01 09:29:43
date last changed
2016-11-27 04:42:30
@misc{02636649-dbda-41a0-b39c-fb8bea001b99,
  abstract     = {<p>Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across sites from around the world, dubbed "The QUASAR reproducibility study". Altogether, 28 sites located in Asia, Europe and North America participated and a total of 284 healthy volunteers were scanned. Minimal operator dependence was assured by using an automatic planning tool and its accuracy and potential usefulness in multi-center trials was evaluated as well. Accurate repositioning between sessions was achieved with the automatic planning tool showing mean displacements of 1.87+/-0.95 mm and rotations of 1.56+/-0.66 degrees . Mean gray matter CBF was 47.4+/-7.5 [ml/100 g/min] with a between-subject standard variation SD(b)=5.5 [ml/100 g/min] and a within-subject standard deviation SD(w)=4.7 [ml/100 g/min]. The corresponding repeatability was 13.0 [ml/100 g/min] and was found to be within the range of previous studies.</p>},
  author       = {Petersen, Esben Thade and Mouridsen, Kim and Golay, Xavier and , },
  issn         = {1095-9572},
  keyword      = {Adolescent,Adult,Aged,Blood Volume,Brain Mapping,Cerebral Arteries,Cerebrovascular Circulation,Female,Humans,Male,Middle Aged,Reproducibility of Results,Software,Spin Labels,Young Adult},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {13--104},
  publisher    = {ARRAY(0xb31a658)},
  series       = {NeuroImage},
  title        = {The QUASAR reproducibility study, Part II : Results from a multi-center Arterial Spin Labeling test-retest study},
  url          = {http://dx.doi.org/10.1016/j.neuroimage.2009.07.068},
  volume       = {49},
  year         = {2010},
}