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Preoperative treatment of anemic women with epoetin beta

Larson, B.; Bremme, K.; Clyne, N. LU and Nordström, L. LU (2001) In Acta Obstetricia et Gynecologica Scandinavica 80(6). p.559-562
Abstract

Aim. To compare the effects of preoperative treatment with recombinant human erythropoietin (EPO) and iron with iron only on hemoglobin levels (Hb) in anemic women prior to hysterectomy. Methods. The study was an open-labelled randomized parallel study. Fifteen women scheduled for hysterectomy due to uterine myoma were given oral iron and EPO (NeoRecormon®) 4 weeks prior to surgery (group I) and 16 women were given oral iron only (group II). Results. Group I showed a significantly greater increase in mean Hb during the pre-surgery study period compared with group II (p=0.007). Two weeks postoperatively, however, there was no significant difference in mean Hb between the two groups. Conclusion. We found that a significantly greater... (More)

Aim. To compare the effects of preoperative treatment with recombinant human erythropoietin (EPO) and iron with iron only on hemoglobin levels (Hb) in anemic women prior to hysterectomy. Methods. The study was an open-labelled randomized parallel study. Fifteen women scheduled for hysterectomy due to uterine myoma were given oral iron and EPO (NeoRecormon®) 4 weeks prior to surgery (group I) and 16 women were given oral iron only (group II). Results. Group I showed a significantly greater increase in mean Hb during the pre-surgery study period compared with group II (p=0.007). Two weeks postoperatively, however, there was no significant difference in mean Hb between the two groups. Conclusion. We found that a significantly greater increase in Hb was achieved with iron in combination with EPO, although in most cases iron only seemed to be as efficacious as iron+EPO in correcting anemia in myoma patients pre-operatively.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anemia, Erythropoietin, Menorrhagia, Myoma
in
Acta Obstetricia et Gynecologica Scandinavica
volume
80
issue
6
pages
4 pages
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0034995294
ISSN
0001-6349
DOI
10.1034/j.1600-0412.2001.080006559.x
language
English
LU publication?
no
id
0362ebda-600c-49a1-9242-a7c4ce9e9915
date added to LUP
2016-08-30 21:52:36
date last changed
2016-09-16 15:09:49
@misc{0362ebda-600c-49a1-9242-a7c4ce9e9915,
  abstract     = {<p>Aim. To compare the effects of preoperative treatment with recombinant human erythropoietin (EPO) and iron with iron only on hemoglobin levels (Hb) in anemic women prior to hysterectomy. Methods. The study was an open-labelled randomized parallel study. Fifteen women scheduled for hysterectomy due to uterine myoma were given oral iron and EPO (NeoRecormon®) 4 weeks prior to surgery (group I) and 16 women were given oral iron only (group II). Results. Group I showed a significantly greater increase in mean Hb during the pre-surgery study period compared with group II (p=0.007). Two weeks postoperatively, however, there was no significant difference in mean Hb between the two groups. Conclusion. We found that a significantly greater increase in Hb was achieved with iron in combination with EPO, although in most cases iron only seemed to be as efficacious as iron+EPO in correcting anemia in myoma patients pre-operatively.</p>},
  author       = {Larson, B. and Bremme, K. and Clyne, N. and Nordström, L.},
  issn         = {0001-6349},
  keyword      = {Anemia,Erythropoietin,Menorrhagia,Myoma},
  language     = {eng},
  number       = {6},
  pages        = {559--562},
  publisher    = {ARRAY(0xa71bfa8)},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Preoperative treatment of anemic women with epoetin beta},
  url          = {http://dx.doi.org/10.1034/j.1600-0412.2001.080006559.x},
  volume       = {80},
  year         = {2001},
}