Advanced

Plasma levels of beta-2 microglobulin in rheumatoid arthritis.

Sjöblom, K G; Saxne, Tore LU and Wollheim, Frank LU (1980) In Annals of the Rheumatic Diseases 39(4). p.333-339
Abstract
A simple and inexpensive method is described for the determination of beta 2-microglobulin (beta 2-MG) by enzyme-amplified single radial immunodiffusion. The values obtained with this method correlate well with those determined by means of a commerical RIA kit. Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA) and normal serum creatinine levels. 33% of the patients had increased concentrations of beta 2 MG, but the levels were found to correlate poorly with the values of several variables generally used as indices of the degree inflammatory activity in RA. Furthermore, in contrast to earlier claims to the contrary, beta 2-MG correlated positively with age. The... (More)
A simple and inexpensive method is described for the determination of beta 2-microglobulin (beta 2-MG) by enzyme-amplified single radial immunodiffusion. The values obtained with this method correlate well with those determined by means of a commerical RIA kit. Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA) and normal serum creatinine levels. 33% of the patients had increased concentrations of beta 2 MG, but the levels were found to correlate poorly with the values of several variables generally used as indices of the degree inflammatory activity in RA. Furthermore, in contrast to earlier claims to the contrary, beta 2-MG correlated positively with age. The value of beta 2-MG in plasma as an index of inflammatory activity in RA is questioned.
(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
beta2-microglobulin, reumatologi
in
Annals of the Rheumatic Diseases
volume
39
issue
4
pages
333 - 339
publisher
British Medical Association
ISSN
1468-2060
language
English
LU publication?
yes
id
0560739a-5e0c-4cf0-a399-22bd07de4e3d
date added to LUP
2016-05-06 15:33:44
date last changed
2016-05-20 13:03:08
@misc{0560739a-5e0c-4cf0-a399-22bd07de4e3d,
  abstract     = {A simple and inexpensive method is described for the determination of beta 2-microglobulin (beta 2-MG) by enzyme-amplified single radial immunodiffusion. The values obtained with this method correlate well with those determined by means of a commerical RIA kit. Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA) and normal serum creatinine levels. 33% of the patients had increased concentrations of beta 2 MG, but the levels were found to correlate poorly with the values of several variables generally used as indices of the degree inflammatory activity in RA. Furthermore, in contrast to earlier claims to the contrary, beta 2-MG correlated positively with age. The value of beta 2-MG in plasma as an index of inflammatory activity in RA is questioned.<br/>},
  author       = {Sjöblom, K G and Saxne, Tore and Wollheim, Frank},
  issn         = {1468-2060},
  keyword      = {beta2-microglobulin,reumatologi},
  language     = {eng},
  number       = {4},
  pages        = {333--339},
  publisher    = {ARRAY(0xa2805c0)},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Plasma levels of beta-2 microglobulin in rheumatoid arthritis.},
  volume       = {39},
  year         = {1980},
}