Advanced

Milk miRNAs : Simple nutrients or systemic functional regulators?

Melnik, Bodo C.; Kakulas, Foteini; Geddes, Donna T.; Hartmann, Peter E.; John, Swen Malte; Carrera-Bastos, Pedro LU ; Cordain, Loren and Schmitz, Gerd (2016) In Nutrition & Metabolism 13(1).
Abstract

Milk is rich in miRNAs that appear to play important roles in the postnatal development of all mammals. Currently, two competing hypotheses exist: the functional hypothesis, which proposes that milk miRNAs are transferred to the offspring and exert physiological regulatory functions, and the nutritional hypothesis, which suggests that these molecules do not reach the systemic circulation of the milk recipient, but merely provide nutrition without conferring active regulatory signals to the offspring. The functional hypothesis is based on indirect evidence and requires further investigation. The nutritional hypothesis is primarily based on three mouse models, which are inherently problematic: 1) miRNA-375 KO mice, 2) miRNA-200c/141 KO... (More)

Milk is rich in miRNAs that appear to play important roles in the postnatal development of all mammals. Currently, two competing hypotheses exist: the functional hypothesis, which proposes that milk miRNAs are transferred to the offspring and exert physiological regulatory functions, and the nutritional hypothesis, which suggests that these molecules do not reach the systemic circulation of the milk recipient, but merely provide nutrition without conferring active regulatory signals to the offspring. The functional hypothesis is based on indirect evidence and requires further investigation. The nutritional hypothesis is primarily based on three mouse models, which are inherently problematic: 1) miRNA-375 KO mice, 2) miRNA-200c/141 KO mice, and 3) transgenic mice presenting high levels of miRNA-30b in milk. This article presents circumstantial evidence that these mouse models may all be inappropriate to study the physiological traffic of milk miRNAs to the newborn mammal, and calls for new studies using more relevant mouse models or human milk to address the fate and role of milk miRNAs in the offspring and the adult consumer of cow's milk.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endocytosis, Exosomes, Gene regulation, Intestinal uptake, Lactation, Mammary gland, Milk, miRNA, miRNA degradation, Mouse models
in
Nutrition & Metabolism
volume
13
issue
1
publisher
BioMed Central
external identifiers
  • Scopus:84975794218
ISSN
1743-7075
DOI
10.1186/s12986-016-0101-2
language
English
LU publication?
yes
id
07921c1c-539b-4003-b21d-b7c3b7445163
date added to LUP
2016-07-21 15:02:43
date last changed
2016-11-09 08:25:30
@misc{07921c1c-539b-4003-b21d-b7c3b7445163,
  abstract     = {<p>Milk is rich in miRNAs that appear to play important roles in the postnatal development of all mammals. Currently, two competing hypotheses exist: the functional hypothesis, which proposes that milk miRNAs are transferred to the offspring and exert physiological regulatory functions, and the nutritional hypothesis, which suggests that these molecules do not reach the systemic circulation of the milk recipient, but merely provide nutrition without conferring active regulatory signals to the offspring. The functional hypothesis is based on indirect evidence and requires further investigation. The nutritional hypothesis is primarily based on three mouse models, which are inherently problematic: 1) miRNA-375 KO mice, 2) miRNA-200c/141 KO mice, and 3) transgenic mice presenting high levels of miRNA-30b in milk. This article presents circumstantial evidence that these mouse models may all be inappropriate to study the physiological traffic of milk miRNAs to the newborn mammal, and calls for new studies using more relevant mouse models or human milk to address the fate and role of milk miRNAs in the offspring and the adult consumer of cow's milk.</p>},
  author       = {Melnik, Bodo C. and Kakulas, Foteini and Geddes, Donna T. and Hartmann, Peter E. and John, Swen Malte and Carrera-Bastos, Pedro and Cordain, Loren and Schmitz, Gerd},
  issn         = {1743-7075},
  keyword      = {Endocytosis,Exosomes,Gene regulation,Intestinal uptake,Lactation,Mammary gland,Milk,miRNA,miRNA degradation,Mouse models},
  language     = {eng},
  month        = {06},
  number       = {1},
  publisher    = {ARRAY(0x8d88dd0)},
  series       = {Nutrition & Metabolism},
  title        = {Milk miRNAs : Simple nutrients or systemic functional regulators?},
  url          = {http://dx.doi.org/10.1186/s12986-016-0101-2},
  volume       = {13},
  year         = {2016},
}