Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Infections, antigen-presenting cells, T cells, and immune tolerance : their role in the pathogenesis of immune thrombocytopenia

Semple, John W LU (2009) In Hematology/Oncology Clinics of North America 23(6). p.92-1177
Abstract

In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues that infectious agents and platelets can significantly modulate APCs, which create an environment that dysregulates autoreactive T cells, leading to the production of autoantibodies.

Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Antigen-Presenting Cells, Humans, Immune Tolerance, Infection, Purpura, Thrombocytopenic, Idiopathic, T-Lymphocytes, Journal Article, Review
in
Hematology/Oncology Clinics of North America
volume
23
issue
6
pages
16 pages
publisher
W.B. Saunders
external identifiers
  • scopus:70449650486
  • pmid:19932427
ISSN
0889-8588
DOI
10.1016/j.hoc.2009.08.007
language
English
LU publication?
no
id
0a1bb360-6ffc-4a0f-9b0a-bf55b6dc0ba6
date added to LUP
2016-09-23 12:08:05
date last changed
2024-02-03 00:20:17
@article{0a1bb360-6ffc-4a0f-9b0a-bf55b6dc0ba6,
  abstract     = {{<p>In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues that infectious agents and platelets can significantly modulate APCs, which create an environment that dysregulates autoreactive T cells, leading to the production of autoantibodies.</p>}},
  author       = {{Semple, John W}},
  issn         = {{0889-8588}},
  keywords     = {{Animals; Antigen-Presenting Cells; Humans; Immune Tolerance; Infection; Purpura, Thrombocytopenic, Idiopathic; T-Lymphocytes; Journal Article; Review}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{92--1177}},
  publisher    = {{W.B. Saunders}},
  series       = {{Hematology/Oncology Clinics of North America}},
  title        = {{Infections, antigen-presenting cells, T cells, and immune tolerance : their role in the pathogenesis of immune thrombocytopenia}},
  url          = {{http://dx.doi.org/10.1016/j.hoc.2009.08.007}},
  doi          = {{10.1016/j.hoc.2009.08.007}},
  volume       = {{23}},
  year         = {{2009}},
}