Infections, antigen-presenting cells, T cells, and immune tolerance : their role in the pathogenesis of immune thrombocytopenia
(2009) In Hematology/Oncology Clinics of North America 23(6). p.92-1177- Abstract
In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues that infectious agents and platelets can significantly modulate APCs, which create an environment that dysregulates autoreactive T cells, leading to the production of autoantibodies.
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https://lup.lub.lu.se/record/0a1bb360-6ffc-4a0f-9b0a-bf55b6dc0ba6
- author
- Semple, John W LU
- publishing date
- 2009-12
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Antigen-Presenting Cells, Humans, Immune Tolerance, Infection, Purpura, Thrombocytopenic, Idiopathic, T-Lymphocytes, Journal Article, Review
- in
- Hematology/Oncology Clinics of North America
- volume
- 23
- issue
- 6
- pages
- 16 pages
- publisher
- W.B. Saunders
- external identifiers
-
- scopus:70449650486
- pmid:19932427
- ISSN
- 0889-8588
- DOI
- 10.1016/j.hoc.2009.08.007
- language
- English
- LU publication?
- no
- id
- 0a1bb360-6ffc-4a0f-9b0a-bf55b6dc0ba6
- date added to LUP
- 2016-09-23 12:08:05
- date last changed
- 2024-02-03 00:20:17
@article{0a1bb360-6ffc-4a0f-9b0a-bf55b6dc0ba6, abstract = {{<p>In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues that infectious agents and platelets can significantly modulate APCs, which create an environment that dysregulates autoreactive T cells, leading to the production of autoantibodies.</p>}}, author = {{Semple, John W}}, issn = {{0889-8588}}, keywords = {{Animals; Antigen-Presenting Cells; Humans; Immune Tolerance; Infection; Purpura, Thrombocytopenic, Idiopathic; T-Lymphocytes; Journal Article; Review}}, language = {{eng}}, number = {{6}}, pages = {{92--1177}}, publisher = {{W.B. Saunders}}, series = {{Hematology/Oncology Clinics of North America}}, title = {{Infections, antigen-presenting cells, T cells, and immune tolerance : their role in the pathogenesis of immune thrombocytopenia}}, url = {{http://dx.doi.org/10.1016/j.hoc.2009.08.007}}, doi = {{10.1016/j.hoc.2009.08.007}}, volume = {{23}}, year = {{2009}}, }