Advanced

Infections, antigen-presenting cells, T cells, and immune tolerance : their role in the pathogenesis of immune thrombocytopenia

Semple, John W LU (2009) In Hematology/Oncology Clinics of North America 23(6). p.92-1177
Abstract

In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues that infectious agents and platelets can significantly modulate APCs, which create an environment that dysregulates autoreactive T cells, leading to the production of autoantibodies.

Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Antigen-Presenting Cells, Humans, Immune Tolerance, Infection, Purpura, Thrombocytopenic, Idiopathic, T-Lymphocytes, Journal Article, Review
in
Hematology/Oncology Clinics of North America
volume
23
issue
6
pages
16 pages
publisher
W B Saunders
external identifiers
  • Scopus:70449650486
ISSN
0889-8588
DOI
10.1016/j.hoc.2009.08.007
language
English
LU publication?
no
id
0a1bb360-6ffc-4a0f-9b0a-bf55b6dc0ba6
date added to LUP
2016-09-23 12:08:05
date last changed
2016-10-13 05:14:18
@misc{0a1bb360-6ffc-4a0f-9b0a-bf55b6dc0ba6,
  abstract     = {<p>In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues that infectious agents and platelets can significantly modulate APCs, which create an environment that dysregulates autoreactive T cells, leading to the production of autoantibodies.</p>},
  author       = {Semple, John W},
  issn         = {0889-8588},
  keyword      = {Animals,Antigen-Presenting Cells,Humans,Immune Tolerance,Infection,Purpura, Thrombocytopenic, Idiopathic,T-Lymphocytes,Journal Article,Review},
  language     = {eng},
  number       = {6},
  pages        = {92--1177},
  publisher    = {ARRAY(0x842e6d0)},
  series       = {Hematology/Oncology Clinics of North America},
  title        = {Infections, antigen-presenting cells, T cells, and immune tolerance : their role in the pathogenesis of immune thrombocytopenia},
  url          = {http://dx.doi.org/10.1016/j.hoc.2009.08.007},
  volume       = {23},
  year         = {2009},
}