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The pancreatic β-cell : A bioenergetic perspective

Nicholls, David G. LU (2016) In Physiological Reviews 96(4). p.1385-1447
Abstract

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review applies an external bioenergetic critique to the central processes of glucose-stimulated insulin secretion, including glycolytic and mitochondrial metabolism, the cytosolic adenine nucleotide pool, and its interaction with plasma membrane ion channels. The control mechanisms responsible for the unique responsiveness of the cell to glucose availability are discussed from bioen-ergetic and metabolic control standpoints. The concept of coupling factor facilitation of secretion is critiqued, and an attempt is made to unravel the bioenergetic basis of the oscillatory mechanisms controlling secretion. The need to consider the physiological constraints... (More)

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review applies an external bioenergetic critique to the central processes of glucose-stimulated insulin secretion, including glycolytic and mitochondrial metabolism, the cytosolic adenine nucleotide pool, and its interaction with plasma membrane ion channels. The control mechanisms responsible for the unique responsiveness of the cell to glucose availability are discussed from bioen-ergetic and metabolic control standpoints. The concept of coupling factor facilitation of secretion is critiqued, and an attempt is made to unravel the bioenergetic basis of the oscillatory mechanisms controlling secretion. The need to consider the physiological constraints operating in the intact cell is emphasized throughout. The aim is to provide a coherent pathway through an extensive, complex, and sometimes bewildering literature, particularly for those unfamiliar with the field.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physiological Reviews
volume
96
issue
4
pages
63 pages
publisher
American Physiological Society
external identifiers
  • Scopus:84986626923
ISSN
0031-9333
DOI
10.1152/physrev.00009.2016
language
English
LU publication?
yes
id
0cd352dc-34eb-4ebf-9c54-106862e72a1f
date added to LUP
2016-10-03 13:37:58
date last changed
2016-10-04 03:00:02
@misc{0cd352dc-34eb-4ebf-9c54-106862e72a1f,
  abstract     = {<p>The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review applies an external bioenergetic critique to the central processes of glucose-stimulated insulin secretion, including glycolytic and mitochondrial metabolism, the cytosolic adenine nucleotide pool, and its interaction with plasma membrane ion channels. The control mechanisms responsible for the unique responsiveness of the cell to glucose availability are discussed from bioen-ergetic and metabolic control standpoints. The concept of coupling factor facilitation of secretion is critiqued, and an attempt is made to unravel the bioenergetic basis of the oscillatory mechanisms controlling secretion. The need to consider the physiological constraints operating in the intact cell is emphasized throughout. The aim is to provide a coherent pathway through an extensive, complex, and sometimes bewildering literature, particularly for those unfamiliar with the field.</p>},
  author       = {Nicholls, David G.},
  issn         = {0031-9333},
  language     = {eng},
  month        = {10},
  number       = {4},
  pages        = {1385--1447},
  publisher    = {ARRAY(0xaec2438)},
  series       = {Physiological Reviews},
  title        = {The pancreatic β-cell : A bioenergetic perspective},
  url          = {http://dx.doi.org/10.1152/physrev.00009.2016},
  volume       = {96},
  year         = {2016},
}