Transcriptional adaptation of neuroblastoma cells to hypoxia.
(2008) In Biochemical and Biophysical Research Communications 366(4). p.1054-1060- Abstract
- Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are... (More)
- Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are correlated to known hypoxia-induced transcriptional profiles. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1034980
- author
- Fredlund, Erik LU ; Ovenberger, Marie LU ; Borg, Ke and Påhlman, Sven LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hypoxia-Inducible Factor 1: metabolism, Neuroblastoma: pathology, Neuroblastoma: genetics
- in
- Biochemical and Biophysical Research Communications
- volume
- 366
- issue
- 4
- pages
- 1054 - 1060
- publisher
- Elsevier
- external identifiers
-
- pmid:18155155
- wos:000252512800032
- scopus:37549043844
- pmid:18155155
- ISSN
- 1090-2104
- DOI
- 10.1016/j.bbrc.2007.12.074
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Medicine (013031200)
- id
- 74e771ff-ec72-4e1c-b722-8522431288f4 (old id 1034980)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18155155?dopt=Abstract
- date added to LUP
- 2016-04-04 09:14:01
- date last changed
- 2022-01-29 08:55:21
@article{74e771ff-ec72-4e1c-b722-8522431288f4,
abstract = {{Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are correlated to known hypoxia-induced transcriptional profiles.}},
author = {{Fredlund, Erik and Ovenberger, Marie and Borg, Ke and Påhlman, Sven}},
issn = {{1090-2104}},
keywords = {{Hypoxia-Inducible Factor 1: metabolism; Neuroblastoma: pathology; Neuroblastoma: genetics}},
language = {{eng}},
number = {{4}},
pages = {{1054--1060}},
publisher = {{Elsevier}},
series = {{Biochemical and Biophysical Research Communications}},
title = {{Transcriptional adaptation of neuroblastoma cells to hypoxia.}},
url = {{http://dx.doi.org/10.1016/j.bbrc.2007.12.074}},
doi = {{10.1016/j.bbrc.2007.12.074}},
volume = {{366}},
year = {{2008}},
}