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Transcriptional adaptation of neuroblastoma cells to hypoxia.

Fredlund, Erik LU ; Ovenberger, Marie LU ; Borg, Ke and Påhlman, Sven LU (2008) In Biochemical and Biophysical Research Communications 366(4). p.1054-1060
Abstract
Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are... (More)
Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are correlated to known hypoxia-induced transcriptional profiles. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hypoxia-Inducible Factor 1: metabolism, Neuroblastoma: pathology, Neuroblastoma: genetics
in
Biochemical and Biophysical Research Communications
volume
366
issue
4
pages
1054 - 1060
publisher
Elsevier
external identifiers
  • PMID:18155155
  • WOS:000252512800032
  • Scopus:37549043844
ISSN
1090-2104
DOI
10.1016/j.bbrc.2007.12.074
language
English
LU publication?
yes
id
74e771ff-ec72-4e1c-b722-8522431288f4 (old id 1034980)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18155155?dopt=Abstract
date added to LUP
2008-04-01 11:30:18
date last changed
2016-12-04 04:38:20
@misc{74e771ff-ec72-4e1c-b722-8522431288f4,
  abstract     = {Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are correlated to known hypoxia-induced transcriptional profiles.},
  author       = {Fredlund, Erik and Ovenberger, Marie and Borg, Ke and Påhlman, Sven},
  issn         = {1090-2104},
  keyword      = {Hypoxia-Inducible Factor 1: metabolism,Neuroblastoma: pathology,Neuroblastoma: genetics},
  language     = {eng},
  number       = {4},
  pages        = {1054--1060},
  publisher    = {ARRAY(0x868d2f0)},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Transcriptional adaptation of neuroblastoma cells to hypoxia.},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2007.12.074},
  volume       = {366},
  year         = {2008},
}