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Self-rated health and classical risk factors for coronary heart disease predict development of erectile dysfunction 25 years later.

Borgquist, Rasmus LU ; Leosdottir, Margrét LU ; Nilsson, Peter LU and Willenheimer, Ronnie LU (2008) In International Journal of Clinical Practice 62(2). p.206-213
Abstract
Aim: To investigate the impact of classical coronary heart disease (CHD) risk factors on the development of future erectile dysfunction (ED). Methods and results: A total of 830 randomly selected subjects were included. Baseline CHD risk factors were evaluated in relation to ED (evaluated by the International Index of Erectile Function-5 questionnaire) 25 years later. At follow-up, 499 men (60%) had some degree of ED. In age-adjusted logistic regression analysis, self-rated health [odds ratio (OR) 1.59, 95% confidence interval (CI): 1.09-2.31], family history of CHD (OR 1.75, CI: 1.17-2.61), fasting blood glucose (OR 1.52, CI: 1.14-2.02), triglycerides (OR 1.25, CI: 1.01-1.54), systolic blood pressure (SBP) (OR 1.19, CI: 1.04-1.35), body... (More)
Aim: To investigate the impact of classical coronary heart disease (CHD) risk factors on the development of future erectile dysfunction (ED). Methods and results: A total of 830 randomly selected subjects were included. Baseline CHD risk factors were evaluated in relation to ED (evaluated by the International Index of Erectile Function-5 questionnaire) 25 years later. At follow-up, 499 men (60%) had some degree of ED. In age-adjusted logistic regression analysis, self-rated health [odds ratio (OR) 1.59, 95% confidence interval (CI): 1.09-2.31], family history of CHD (OR 1.75, CI: 1.17-2.61), fasting blood glucose (OR 1.52, CI: 1.14-2.02), triglycerides (OR 1.25, CI: 1.01-1.54), systolic blood pressure (SBP) (OR 1.19, CI: 1.04-1.35), body mass index (OR 1.08, CI: 1.03-1.13) and serum glutamyl transferase (GT) (OR 1.81, CI: 1.23-2.68), predicted ED. Independent predictors were higher age, low self-rated health, higher blood glucose, higher GT and a family history of CHD. Higher SBP was borderline significantly independent (p = 0.05). Furthermore, baseline age-adjusted Framingham risk score for CHD, also predicted future ED (OR 1.20, CI: 1.03-1.38). Conclusions: Our study supports and expands previous findings that ED and CHD share many risk factors, further underscoring the close link between ED and CHD. Men presenting with ED should be evaluated for the presence of other CHD risk factors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Clinical Practice
volume
62
issue
2
pages
206 - 213
publisher
Wiley-Blackwell
external identifiers
  • PMID:18070043
  • WOS:000252322200011
  • Scopus:38149127311
ISSN
1742-1241
DOI
10.1111/j.1742-1241.2007.01651.x
language
English
LU publication?
yes
id
3e36c011-fdfa-4759-9290-931487064399 (old id 1035406)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18070043?dopt=Abstract
date added to LUP
2008-02-28 12:24:28
date last changed
2016-10-13 04:33:43
@misc{3e36c011-fdfa-4759-9290-931487064399,
  abstract     = {Aim: To investigate the impact of classical coronary heart disease (CHD) risk factors on the development of future erectile dysfunction (ED). Methods and results: A total of 830 randomly selected subjects were included. Baseline CHD risk factors were evaluated in relation to ED (evaluated by the International Index of Erectile Function-5 questionnaire) 25 years later. At follow-up, 499 men (60%) had some degree of ED. In age-adjusted logistic regression analysis, self-rated health [odds ratio (OR) 1.59, 95% confidence interval (CI): 1.09-2.31], family history of CHD (OR 1.75, CI: 1.17-2.61), fasting blood glucose (OR 1.52, CI: 1.14-2.02), triglycerides (OR 1.25, CI: 1.01-1.54), systolic blood pressure (SBP) (OR 1.19, CI: 1.04-1.35), body mass index (OR 1.08, CI: 1.03-1.13) and serum glutamyl transferase (GT) (OR 1.81, CI: 1.23-2.68), predicted ED. Independent predictors were higher age, low self-rated health, higher blood glucose, higher GT and a family history of CHD. Higher SBP was borderline significantly independent (p = 0.05). Furthermore, baseline age-adjusted Framingham risk score for CHD, also predicted future ED (OR 1.20, CI: 1.03-1.38). Conclusions: Our study supports and expands previous findings that ED and CHD share many risk factors, further underscoring the close link between ED and CHD. Men presenting with ED should be evaluated for the presence of other CHD risk factors.},
  author       = {Borgquist, Rasmus and Leosdottir, Margrét and Nilsson, Peter and Willenheimer, Ronnie},
  issn         = {1742-1241},
  language     = {eng},
  number       = {2},
  pages        = {206--213},
  publisher    = {ARRAY(0x9883130)},
  series       = {International Journal of Clinical Practice},
  title        = {Self-rated health and classical risk factors for coronary heart disease predict development of erectile dysfunction 25 years later.},
  url          = {http://dx.doi.org/10.1111/j.1742-1241.2007.01651.x},
  volume       = {62},
  year         = {2008},
}