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A Subset of CD5- Diffuse Large B-Cell Lymphomas Expresses Nuclear Cyclin D1 With Aberrations at the CCND1 Locus.

Ehinger, Mats LU ; Linderoth, Johan LU ; Christensson, Birger; Sander, Birgitta and Cavallin-Ståhl, Eva LU (2008) In American Journal of Clinical Pathology 129(4). p.630-638
Abstract
In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number... (More)
In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number of cyclin D1+ and CD5- diffuse large B-cell lymphomas, some of which have structural aberrations at the CCND1 locus, including the t(11;14). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Clinical Pathology
volume
129
issue
4
pages
630 - 638
publisher
American Society for Clinical Pathology
external identifiers
  • PMID:18343791
  • WOS:000254127600015
  • Scopus:42949153437
ISSN
1943-7722
DOI
10.1309/42CQ0HU7XEY9QMQX
language
English
LU publication?
yes
id
ad348052-69b1-4955-8cd1-10dba4a0acd3 (old id 1052448)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18343791?dopt=Abstract
date added to LUP
2008-04-01 11:13:02
date last changed
2016-10-13 04:34:58
@misc{ad348052-69b1-4955-8cd1-10dba4a0acd3,
  abstract     = {In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number of cyclin D1+ and CD5- diffuse large B-cell lymphomas, some of which have structural aberrations at the CCND1 locus, including the t(11;14).},
  author       = {Ehinger, Mats and Linderoth, Johan and Christensson, Birger and Sander, Birgitta and Cavallin-Ståhl, Eva},
  issn         = {1943-7722},
  language     = {eng},
  number       = {4},
  pages        = {630--638},
  publisher    = {ARRAY(0x9306a98)},
  series       = {American Journal of Clinical Pathology},
  title        = {A Subset of CD5- Diffuse Large B-Cell Lymphomas Expresses Nuclear Cyclin D1 With Aberrations at the CCND1 Locus.},
  url          = {http://dx.doi.org/10.1309/42CQ0HU7XEY9QMQX},
  volume       = {129},
  year         = {2008},
}