Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

A Subset of CD5- Diffuse Large B-Cell Lymphomas Expresses Nuclear Cyclin D1 With Aberrations at the CCND1 Locus.

Ehinger, Mats LU ; Linderoth, Johan LU ; Christensson, Birger ; Sander, Birgitta and Cavallin-Ståhl, Eva LU (2008) In American Journal of Clinical Pathology 129(4). p.630-638
Abstract
In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number... (More)
In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number of cyclin D1+ and CD5- diffuse large B-cell lymphomas, some of which have structural aberrations at the CCND1 locus, including the t(11;14). (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Clinical Pathology
volume
129
issue
4
pages
630 - 638
publisher
Oxford University Press
external identifiers
  • pmid:18343791
  • wos:000254127600015
  • scopus:42949153437
ISSN
1943-7722
DOI
10.1309/42CQ0HU7XEY9QMQX
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)
id
ad348052-69b1-4955-8cd1-10dba4a0acd3 (old id 1052448)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18343791?dopt=Abstract
date added to LUP
2016-04-04 09:40:20
date last changed
2022-04-16 00:30:24
@article{ad348052-69b1-4955-8cd1-10dba4a0acd3,
  abstract     = {{In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluorescence signals indicative of the t(11;14). Two other cases displayed additional cyclin D1 signals in the absence of the t(11;14). All cases but 1 were positive for bcl-6 or MUM1, disfavoring the possibility of misdiagnosed blastoid variants of CD5- mantle cell lymphomas. Thus, contrary to the current view, there seems to exist a certain number of cyclin D1+ and CD5- diffuse large B-cell lymphomas, some of which have structural aberrations at the CCND1 locus, including the t(11;14).}},
  author       = {{Ehinger, Mats and Linderoth, Johan and Christensson, Birger and Sander, Birgitta and Cavallin-Ståhl, Eva}},
  issn         = {{1943-7722}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{630--638}},
  publisher    = {{Oxford University Press}},
  series       = {{American Journal of Clinical Pathology}},
  title        = {{A Subset of CD5- Diffuse Large B-Cell Lymphomas Expresses Nuclear Cyclin D1 With Aberrations at the CCND1 Locus.}},
  url          = {{http://dx.doi.org/10.1309/42CQ0HU7XEY9QMQX}},
  doi          = {{10.1309/42CQ0HU7XEY9QMQX}},
  volume       = {{129}},
  year         = {{2008}},
}