Molecular and pathological characterization of inherited breast cancer.
(2001) In Seminars in Cancer Biology 11(5). p.375-385- Abstract
- The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast–ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsuccessful, probably due to genetic heterogeneity. Pooling of families of different ethnical, cultural, and geographical origin proved to be a useful approach when identifying BRCA1 and BRCA2, but for genes mutated only in specific populations it is important not to introduce locus heterogeneity by pooling. Genetic heterogeneity can possibly be circumvented by using objective means, such as tumour histopathology or gene expression... (More)
- The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast–ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsuccessful, probably due to genetic heterogeneity. Pooling of families of different ethnical, cultural, and geographical origin proved to be a useful approach when identifying BRCA1 and BRCA2, but for genes mutated only in specific populations it is important not to introduce locus heterogeneity by pooling. Genetic heterogeneity can possibly be circumvented by using objective means, such as tumour histopathology or gene expression profiling, for subclassification of families prior to linkage analysis. Also, additional breast cancer genes can be identified by further characterization of the function of BRCA1 and BRCA2 and their interacting proteins. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121626
- author
- Borg, Åke LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- breast cancer, BRCA1, BRCA2, molecular characterization, pathological characterization
- in
- Seminars in Cancer Biology
- volume
- 11
- issue
- 5
- pages
- 375 - 385
- publisher
- Academic Press
- external identifiers
-
- wos:000171560700007
- scopus:0034751402
- pmid:11562180
- ISSN
- 1096-3650
- DOI
- 10.1006/scbi.2001.0393
- language
- English
- LU publication?
- yes
- id
- c3b49d92-c523-4dc3-8a45-bc67e97b3284 (old id 1121626)
- date added to LUP
- 2016-04-04 11:42:38
- date last changed
- 2022-01-29 22:20:18
@article{c3b49d92-c523-4dc3-8a45-bc67e97b3284,
abstract = {{The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast–ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsuccessful, probably due to genetic heterogeneity. Pooling of families of different ethnical, cultural, and geographical origin proved to be a useful approach when identifying BRCA1 and BRCA2, but for genes mutated only in specific populations it is important not to introduce locus heterogeneity by pooling. Genetic heterogeneity can possibly be circumvented by using objective means, such as tumour histopathology or gene expression profiling, for subclassification of families prior to linkage analysis. Also, additional breast cancer genes can be identified by further characterization of the function of BRCA1 and BRCA2 and their interacting proteins.}},
author = {{Borg, Åke}},
issn = {{1096-3650}},
keywords = {{breast cancer; BRCA1; BRCA2; molecular characterization; pathological characterization}},
language = {{eng}},
number = {{5}},
pages = {{375--385}},
publisher = {{Academic Press}},
series = {{Seminars in Cancer Biology}},
title = {{Molecular and pathological characterization of inherited breast cancer.}},
url = {{http://dx.doi.org/10.1006/scbi.2001.0393}},
doi = {{10.1006/scbi.2001.0393}},
volume = {{11}},
year = {{2001}},
}