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Galectins structure and function--a synopsis

Leffler, Hakon LU (2001) In Results and Problems in Cell Differentiation 33. p.57-83
Abstract
The 20 or so galectins expected to be found in man, and their many possible functional effects promise a rich and fruitful research field in the future. At present, the biomedically most promising areas for use of galectins or their ligands are in inflammation, immunity, and cancer. Many good stories can be formulated, but the field lacks the cohesion of knowing basic galectin function. The only basic common denominators among galectins are beta-galactoside binding, and the unusual combination of intra- and extracellular expression with non-classical secretion in between. Maybe that is all there is, and nature has used these properties for multiple, otherwise unrelated functions. Then again, maybe there is some deeper common function that... (More)
The 20 or so galectins expected to be found in man, and their many possible functional effects promise a rich and fruitful research field in the future. At present, the biomedically most promising areas for use of galectins or their ligands are in inflammation, immunity, and cancer. Many good stories can be formulated, but the field lacks the cohesion of knowing basic galectin function. The only basic common denominators among galectins are beta-galactoside binding, and the unusual combination of intra- and extracellular expression with non-classical secretion in between. Maybe that is all there is, and nature has used these properties for multiple, otherwise unrelated functions. Then again, maybe there is some deeper common function that has so far been overlooked. If it exists, this probably lies somewhere in the detailed integration of galectin activity in the complexities of cell physiology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Results and Problems in Cell Differentiation
volume
33
pages
57 - 83
publisher
Springer Verlag
external identifiers
  • PMID:11190679
  • Scopus:0035233969
ISSN
0080-1844
language
English
LU publication?
yes
id
c0275c63-771c-4310-83dc-5e978c6e5827 (old id 1123031)
date added to LUP
2008-07-03 10:36:52
date last changed
2016-10-23 04:30:37
@misc{c0275c63-771c-4310-83dc-5e978c6e5827,
  abstract     = {The 20 or so galectins expected to be found in man, and their many possible functional effects promise a rich and fruitful research field in the future. At present, the biomedically most promising areas for use of galectins or their ligands are in inflammation, immunity, and cancer. Many good stories can be formulated, but the field lacks the cohesion of knowing basic galectin function. The only basic common denominators among galectins are beta-galactoside binding, and the unusual combination of intra- and extracellular expression with non-classical secretion in between. Maybe that is all there is, and nature has used these properties for multiple, otherwise unrelated functions. Then again, maybe there is some deeper common function that has so far been overlooked. If it exists, this probably lies somewhere in the detailed integration of galectin activity in the complexities of cell physiology.},
  author       = {Leffler, Hakon},
  issn         = {0080-1844},
  language     = {eng},
  pages        = {57--83},
  publisher    = {ARRAY(0xb7a8590)},
  series       = {Results and Problems in Cell Differentiation},
  title        = {Galectins structure and function--a synopsis},
  volume       = {33},
  year         = {2001},
}