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Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by fractal methods

Podsiadlo, P; Dahl, Ludvig LU ; Englund, Martin LU ; Lohmander, Stefan LU and Stachowiak, GW (2008) In Osteoarthritis and Cartilage 16(3). p.323-329
Abstract
Objective



To develop an accurate method for quantifying differences in the trabecular structure in the tibial bone between subjects with and without knee osteoarthritis (OA).

Methods



Standard knee radiographs were taken from 26 subjects (seven women) with meniscectomy and radiographic OA Kellgren & Lawrence grade 2 or worse in the medial compartment. Each case knee was individually matched by sex, age, body mass index and medial or lateral compartment with a control knee.



A newly developed augmented Hurst orientation transform (HOT) method was used to calculate texture parameters for regions selected in X-ray images of non-OA and OA tibial bones. This method produces a... (More)
Objective



To develop an accurate method for quantifying differences in the trabecular structure in the tibial bone between subjects with and without knee osteoarthritis (OA).

Methods



Standard knee radiographs were taken from 26 subjects (seven women) with meniscectomy and radiographic OA Kellgren & Lawrence grade 2 or worse in the medial compartment. Each case knee was individually matched by sex, age, body mass index and medial or lateral compartment with a control knee.



A newly developed augmented Hurst orientation transform (HOT) method was used to calculate texture parameters for regions selected in X-ray images of non-OA and OA tibial bones. This method produces a mean value of fractal dimensions (FDMEAN), FDs in the vertical (FDV) and horizontal (FDH) directions and along a direction of the roughest part of the tibial bone (FDSta), fractal signatures and a texture aspect ratio (Str). The ratio determines a degree of the bone texture anisotropy. Reproducibility was calculated using an intraclass correlation coefficient (ICC). Comparisons between cases and controls were made with paired t tests. The performance of the HOT method was evaluated against a benchmark fractal signature analysis (FSA) method.

Results



Compared with controls, trabecular bone in OA knees showed significantly lower FDMEAN, FDV, FDH and FDSta and higher Str at trabecular image sizes 0.2–1.1 mm (P < 0.05, HOT). The reproducibility of all parameters was very good (ICC > 0.8). In the medial compartment, fractal signatures calculated for OA horizontal and vertical trabeculae were significantly lower at sizes 0.3–0.55 mm (P < 0.05, HOT) and 0.3–0.65 mm (P < 0.001, FSA). In the lateral compartment, FDs calculated for OA trabeculae were lower than controls (horizontal: 0.3–0.55 mm (P < 0.05, HOT) and 0.3–0.65 mm (P < 0.001, FSA); vertical: 0.3–0.4 mm (P < 0.05, HOT) and 0.3–0.35 mm (P < 0.001, FSA).

Conclusion



The augmented HOT method produces fractal signatures that are comparable to those obtained from the benchmark FSA method. The HOT method provides a more detailed description of OA changes in bone anisotropy than the FSA method. This includes a degree of bone anisotropy measured using data from all possible directions and a texture roughness calculated for the roughest part of the bone. It appears that the augmented HOT method is well suited to quantify OA changes in the tibial bone structure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Osteoarthritis and Cartilage
volume
16
issue
3
pages
323 - 329
publisher
Elsevier
external identifiers
  • WOS:000254531000007
  • Scopus:39749093767
ISSN
1063-4584
DOI
10.1016/j.joca.2007.07.010
language
English
LU publication?
yes
id
6fb0c863-15e1-4b3c-961b-441989168d8d (old id 1138197)
date added to LUP
2008-08-06 14:37:14
date last changed
2016-11-15 14:41:00
@misc{6fb0c863-15e1-4b3c-961b-441989168d8d,
  abstract     = {Objective<br/><br>
<br/><br>
To develop an accurate method for quantifying differences in the trabecular structure in the tibial bone between subjects with and without knee osteoarthritis (OA).<br/><br>
Methods<br/><br>
<br/><br>
Standard knee radiographs were taken from 26 subjects (seven women) with meniscectomy and radiographic OA Kellgren &amp; Lawrence grade 2 or worse in the medial compartment. Each case knee was individually matched by sex, age, body mass index and medial or lateral compartment with a control knee.<br/><br>
<br/><br>
A newly developed augmented Hurst orientation transform (HOT) method was used to calculate texture parameters for regions selected in X-ray images of non-OA and OA tibial bones. This method produces a mean value of fractal dimensions (FDMEAN), FDs in the vertical (FDV) and horizontal (FDH) directions and along a direction of the roughest part of the tibial bone (FDSta), fractal signatures and a texture aspect ratio (Str). The ratio determines a degree of the bone texture anisotropy. Reproducibility was calculated using an intraclass correlation coefficient (ICC). Comparisons between cases and controls were made with paired t tests. The performance of the HOT method was evaluated against a benchmark fractal signature analysis (FSA) method.<br/><br>
Results<br/><br>
<br/><br>
Compared with controls, trabecular bone in OA knees showed significantly lower FDMEAN, FDV, FDH and FDSta and higher Str at trabecular image sizes 0.2–1.1 mm (P &lt; 0.05, HOT). The reproducibility of all parameters was very good (ICC &gt; 0.8). In the medial compartment, fractal signatures calculated for OA horizontal and vertical trabeculae were significantly lower at sizes 0.3–0.55 mm (P &lt; 0.05, HOT) and 0.3–0.65 mm (P &lt; 0.001, FSA). In the lateral compartment, FDs calculated for OA trabeculae were lower than controls (horizontal: 0.3–0.55 mm (P &lt; 0.05, HOT) and 0.3–0.65 mm (P &lt; 0.001, FSA); vertical: 0.3–0.4 mm (P &lt; 0.05, HOT) and 0.3–0.35 mm (P &lt; 0.001, FSA).<br/><br>
Conclusion<br/><br>
<br/><br>
The augmented HOT method produces fractal signatures that are comparable to those obtained from the benchmark FSA method. The HOT method provides a more detailed description of OA changes in bone anisotropy than the FSA method. This includes a degree of bone anisotropy measured using data from all possible directions and a texture roughness calculated for the roughest part of the bone. It appears that the augmented HOT method is well suited to quantify OA changes in the tibial bone structure.},
  author       = {Podsiadlo, P and Dahl, Ludvig and Englund, Martin and Lohmander, Stefan and Stachowiak, GW},
  issn         = {1063-4584},
  language     = {eng},
  number       = {3},
  pages        = {323--329},
  publisher    = {ARRAY(0xaa6a258)},
  series       = {Osteoarthritis and Cartilage},
  title        = {Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by fractal methods},
  url          = {http://dx.doi.org/10.1016/j.joca.2007.07.010},
  volume       = {16},
  year         = {2008},
}