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Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.

Kotsopoulos, J; Lubinski, J; Lynch, HT; Klijn J, Ghadirian, P; Neuhausen, SL; Kim-Sing, C; Foulkes, WD; Moller, P; Isaacs, C and Domchek, S, et al. (2007) In Breast Cancer Res Treat 105(2). p.221-228
Abstract
An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case–control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth... (More)
An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case–control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth in the cases and controls (24.9 years vs. 24.8 years; P = 0.81, respectively). Compared to women whose first child was born at or before 18 years of age, a later age at first full-term birth did not influence the risk of developing breast cancer (OR = 1.00 per year; 95% CI 0.98–1.03; P-trend = 0.67). Stratification by mutation status did not affect the results. These findings suggest that an early first full-term birth does not confer protection against breast cancer in BRCA mutation carriers. Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective. (Less)
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keywords
Case–control study, Breast cancer, BRCA2, Age at first birth, BRCA1
in
Breast Cancer Res Treat
volume
105
issue
2
pages
221 - 228
external identifiers
  • Scopus:34548436454
DOI
10.1007/s10549-006-9441-3
language
English
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yes
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ed3d7690-8fe7-4ecd-80cc-d62014735b5a (old id 1140433)
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2008-08-15 11:09:51
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2016-10-13 05:02:49
@misc{ed3d7690-8fe7-4ecd-80cc-d62014735b5a,
  abstract     = {An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case–control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth in the cases and controls (24.9 years vs. 24.8 years; P = 0.81, respectively). Compared to women whose first child was born at or before 18 years of age, a later age at first full-term birth did not influence the risk of developing breast cancer (OR = 1.00 per year; 95% CI 0.98–1.03; P-trend = 0.67). Stratification by mutation status did not affect the results. These findings suggest that an early first full-term birth does not confer protection against breast cancer in BRCA mutation carriers. Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective.},
  author       = {Kotsopoulos, J and Lubinski, J and Lynch, HT and Klijn J, Ghadirian, P and Neuhausen, SL and Kim-Sing, C and Foulkes, WD and Moller, P and Isaacs, C and Domchek, S and Randall, S and Offit, K and Tung, N and Ainsworth, P and Gershoni-Baruch, R and Eisen, A and Daly, Mark and Karlan, B and Saal, HM and Couch, F and Pasini, Barbara},
  keyword      = {Case–control study,Breast cancer,BRCA2,Age at first birth,BRCA1},
  language     = {eng},
  number       = {2},
  pages        = {221--228},
  series       = {Breast Cancer Res Treat},
  title        = {Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.},
  url          = {http://dx.doi.org/10.1007/s10549-006-9441-3},
  volume       = {105},
  year         = {2007},
}