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Insulinoscillationer--en kliniskt betydelsefull rytmik. Diabeteslakemedel bor oka den pulsatila komponenten av insulinfrisattningen

Hellman, Bo; Gylfe, Erik; Grapengiesser, Eva; Dansk, Helene and Salehi, S Albert LU (2007) In Läkartidningen 104(32-33). p.2236-2239
Abstract
The concentration of circulating insulin oscillates with periods of 3-6 min due to pulsatile release of the hormone from the pancreas. Pulsatile insulin secretion from the individual * cell is driven by slow cycles of Ca2+ elevation due to periodic depolarisation. The Ca2+ oscillations of individual * cells in the islets of Langerhans are entrained into a common rhythm by gap junctional coupling and diffusible factors. Autonomic ganglia coordinate the oscillatory activity of the million islets in the pancreas. ATP binding to purinoceptors causes pronounced Ca2+ spikes that are important for synchronizing the *-cells within and among islets in the pancreas. Inhibition of purinergic P2Y1 receptors selectively abolishes pulsatile insulin... (More)
The concentration of circulating insulin oscillates with periods of 3-6 min due to pulsatile release of the hormone from the pancreas. Pulsatile insulin secretion from the individual * cell is driven by slow cycles of Ca2+ elevation due to periodic depolarisation. The Ca2+ oscillations of individual * cells in the islets of Langerhans are entrained into a common rhythm by gap junctional coupling and diffusible factors. Autonomic ganglia coordinate the oscillatory activity of the million islets in the pancreas. ATP binding to purinoceptors causes pronounced Ca2+ spikes that are important for synchronizing the *-cells within and among islets in the pancreas. Inhibition of purinergic P2Y1 receptors selectively abolishes pulsatile insulin release without reducing the average rate of secretion. The insulin oscillations are particularly important for the liver. This organ is also exposed to oscillating levels of glucagon. The latter oscillations are in opposite phase allowing maximal exposure to insulin when the glucagon concentration is at minimum. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
104
issue
32-33
pages
2236 - 2239
publisher
Sveriges Läkarförbund
external identifiers
  • PMID:17822201
  • Scopus:34548320818
ISSN
0023-7205
language
English
LU publication?
yes
id
ae77d5e3-d2e6-4787-a61a-6c528d345036 (old id 1141715)
alternative location
http://ltarkiv.lakartidningen.se/artNo33719
date added to LUP
2008-08-12 10:12:23
date last changed
2016-10-13 04:28:52
@misc{ae77d5e3-d2e6-4787-a61a-6c528d345036,
  abstract     = {The concentration of circulating insulin oscillates with periods of 3-6 min due to pulsatile release of the hormone from the pancreas. Pulsatile insulin secretion from the individual * cell is driven by slow cycles of Ca2+ elevation due to periodic depolarisation. The Ca2+ oscillations of individual * cells in the islets of Langerhans are entrained into a common rhythm by gap junctional coupling and diffusible factors. Autonomic ganglia coordinate the oscillatory activity of the million islets in the pancreas. ATP binding to purinoceptors causes pronounced Ca2+ spikes that are important for synchronizing the *-cells within and among islets in the pancreas. Inhibition of purinergic P2Y1 receptors selectively abolishes pulsatile insulin release without reducing the average rate of secretion. The insulin oscillations are particularly important for the liver. This organ is also exposed to oscillating levels of glucagon. The latter oscillations are in opposite phase allowing maximal exposure to insulin when the glucagon concentration is at minimum.},
  author       = {Hellman, Bo and Gylfe, Erik and Grapengiesser, Eva and Dansk, Helene and Salehi, S Albert},
  issn         = {0023-7205},
  language     = {eng},
  number       = {32-33},
  pages        = {2236--2239},
  publisher    = {ARRAY(0xa53fa78)},
  series       = {Läkartidningen},
  title        = {Insulinoscillationer--en kliniskt betydelsefull rytmik. Diabeteslakemedel bor oka den pulsatila komponenten av insulinfrisattningen},
  volume       = {104},
  year         = {2007},
}