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Activities of daily living - Outcome during two years in galantamine treated Alzheimer patients

Wattmo, Carina LU ; Wallin, Åsa LU and Minthon, Lennart LU (2007) 8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007) In New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2007 p.251-255
Abstract
122 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were studied with respect to longitudinal change in cognition (MMSE and ADAS-cog) and function (IADL, PSMS and FAST). Particularly the FAST mean change from baseline showed a linear relationship with cognitive mean change and the strength of the relationship increased over time. The IADL scale demonstrated a faster decline of function, but significantly less than expected by using the mathematical model by Green et al. A cluster analysis was performed to reveal any natural groupings of the patients based on the functional scores at baseline. The two-cluster solution was significant; patients in cluster 1 were more cognitively impaired at... (More)
122 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were studied with respect to longitudinal change in cognition (MMSE and ADAS-cog) and function (IADL, PSMS and FAST). Particularly the FAST mean change from baseline showed a linear relationship with cognitive mean change and the strength of the relationship increased over time. The IADL scale demonstrated a faster decline of function, but significantly less than expected by using the mathematical model by Green et al. A cluster analysis was performed to reveal any natural groupings of the patients based on the functional scores at baseline. The two-cluster solution was significant; patients in cluster 1 were more cognitively impaired at baseline, they were less apt to carry the apoE4 allele and declined faster in the outcome of PSMS score compared to the other group. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2007
pages
251 - 255
publisher
Medimond
conference name
8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007)
external identifiers
  • WOS:000257460200036
language
English
LU publication?
yes
id
636285be-fed3-49ac-96d1-39453f8d3a6f (old id 1141935)
date added to LUP
2008-08-08 14:15:35
date last changed
2016-04-16 10:21:17
@misc{636285be-fed3-49ac-96d1-39453f8d3a6f,
  abstract     = {122 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were studied with respect to longitudinal change in cognition (MMSE and ADAS-cog) and function (IADL, PSMS and FAST). Particularly the FAST mean change from baseline showed a linear relationship with cognitive mean change and the strength of the relationship increased over time. The IADL scale demonstrated a faster decline of function, but significantly less than expected by using the mathematical model by Green et al. A cluster analysis was performed to reveal any natural groupings of the patients based on the functional scores at baseline. The two-cluster solution was significant; patients in cluster 1 were more cognitively impaired at baseline, they were less apt to carry the apoE4 allele and declined faster in the outcome of PSMS score compared to the other group.},
  author       = {Wattmo, Carina and Wallin, Åsa and Minthon, Lennart},
  language     = {eng},
  pages        = {251--255},
  publisher    = {ARRAY(0xaede350)},
  series       = {New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2007},
  title        = {Activities of daily living - Outcome during two years in galantamine treated Alzheimer patients},
  year         = {2007},
}