Advanced

Ratings of L-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson's disease in rats and mice.

Cenci Nilsson, Angela LU and Lundblad, Martin LU (2007) In Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] Chapter 9(Oct). p.9-25
Abstract
This unit provides detailed protocols for establishing rodent models of L-DOPA-induced dyskinesia. The 6-hydroxydopamine (6-OHDA) lesion procedure is described in more detail for mice than for rats since the lesioning procedure in rats has been described extensively in previous work and is less difficult to perform. Unlike primate models, rodent models of L-DOPA-induced dyskinesia are relatively simple and fast to set up, thus being affordable to most laboratories. These models allow for studying the dyskinetic complications of L-DOPA treatment on large groups of animals under strictly controlled experimental conditions. Along with information and structured protocols for the practical execution of the test, this unit provides a detailed... (More)
This unit provides detailed protocols for establishing rodent models of L-DOPA-induced dyskinesia. The 6-hydroxydopamine (6-OHDA) lesion procedure is described in more detail for mice than for rats since the lesioning procedure in rats has been described extensively in previous work and is less difficult to perform. Unlike primate models, rodent models of L-DOPA-induced dyskinesia are relatively simple and fast to set up, thus being affordable to most laboratories. These models allow for studying the dyskinetic complications of L-DOPA treatment on large groups of animals under strictly controlled experimental conditions. Along with information and structured protocols for the practical execution of the test, this unit provides a detailed description of the rating scale and the phenomenology of rodent abnormal involuntary movements, and suggestions for beginners. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
volume
Chapter 9
issue
Oct
pages
9 - 25
publisher
John Wiley and Sons Inc.
external identifiers
  • PMID:18428668
  • Scopus:44049103762
ISSN
1934-8576
DOI
10.1002/0471142301.ns0925s41
language
English
LU publication?
yes
id
cbfef00e-507d-40b2-a5aa-5d5b4d4c9922 (old id 1147146)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18428668?dopt=Abstract
date added to LUP
2008-05-08 11:50:14
date last changed
2016-10-13 04:23:18
@misc{cbfef00e-507d-40b2-a5aa-5d5b4d4c9922,
  abstract     = {This unit provides detailed protocols for establishing rodent models of L-DOPA-induced dyskinesia. The 6-hydroxydopamine (6-OHDA) lesion procedure is described in more detail for mice than for rats since the lesioning procedure in rats has been described extensively in previous work and is less difficult to perform. Unlike primate models, rodent models of L-DOPA-induced dyskinesia are relatively simple and fast to set up, thus being affordable to most laboratories. These models allow for studying the dyskinetic complications of L-DOPA treatment on large groups of animals under strictly controlled experimental conditions. Along with information and structured protocols for the practical execution of the test, this unit provides a detailed description of the rating scale and the phenomenology of rodent abnormal involuntary movements, and suggestions for beginners.},
  author       = {Cenci Nilsson, Angela and Lundblad, Martin},
  issn         = {1934-8576},
  language     = {eng},
  number       = {Oct},
  pages        = {9--25},
  publisher    = {ARRAY(0xc6d8110)},
  series       = {Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]},
  title        = {Ratings of L-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson's disease in rats and mice.},
  url          = {http://dx.doi.org/10.1002/0471142301.ns0925s41},
  volume       = {Chapter 9},
  year         = {2007},
}