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Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols.

Padmanabhan, Sandosh; Melander, Olle LU ; Hastie, Claire; Menni, Cristina; Delles, Christian; Connell, John M and Dominiczak, Anna F (2008) In Journal of Hypertension 26(7). p.1275-1281
Abstract
Among the common complex diseases, hypertension has been particularly unlucky in the recent surge of positive results from genome-wide association studies. We summarize the evidence that would support continuing the effort in the hunt for a genetic basis for hypertension. The problems facing the genetic studies for hypertension are not unique, but phenotypic characterization, heterogeneity and high prevalence make it a special case requiring a more individualized approach. We argue that, even in the presence of a strong environmental component to hypertension risk, the common disease/common variant model is relevant for hypertension and discuss the issues involved in designing a genome-wide association study for hypertension. It is likely... (More)
Among the common complex diseases, hypertension has been particularly unlucky in the recent surge of positive results from genome-wide association studies. We summarize the evidence that would support continuing the effort in the hunt for a genetic basis for hypertension. The problems facing the genetic studies for hypertension are not unique, but phenotypic characterization, heterogeneity and high prevalence make it a special case requiring a more individualized approach. We argue that, even in the presence of a strong environmental component to hypertension risk, the common disease/common variant model is relevant for hypertension and discuss the issues involved in designing a genome-wide association study for hypertension. It is likely that the individual odds ratios for disease variants will be less than 1.3 and, although individually these effect sizes are minor, the combination of even a few such common polymorphisms can have substantial population attributable risks. The identification of hypertension gene variants should provide new insight into the disease susceptibility, progression and severity. This will lead to the identification of potential targets for lifestyle and pharmacological interventions, with the ultimate goal of improving prevention, diagnosis and treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
26
issue
7
pages
1275 - 1281
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000257387500001
  • PMID:18550997
  • Scopus:53649090543
ISSN
1473-5598
DOI
10.1097/HJH.0b013e3282ff634f
language
English
LU publication?
yes
id
2a4905d8-8168-4458-b264-45f82fe1add0 (old id 1168854)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18550997?dopt=Abstract
date added to LUP
2008-07-03 13:13:01
date last changed
2016-10-13 04:27:23
@misc{2a4905d8-8168-4458-b264-45f82fe1add0,
  abstract     = {Among the common complex diseases, hypertension has been particularly unlucky in the recent surge of positive results from genome-wide association studies. We summarize the evidence that would support continuing the effort in the hunt for a genetic basis for hypertension. The problems facing the genetic studies for hypertension are not unique, but phenotypic characterization, heterogeneity and high prevalence make it a special case requiring a more individualized approach. We argue that, even in the presence of a strong environmental component to hypertension risk, the common disease/common variant model is relevant for hypertension and discuss the issues involved in designing a genome-wide association study for hypertension. It is likely that the individual odds ratios for disease variants will be less than 1.3 and, although individually these effect sizes are minor, the combination of even a few such common polymorphisms can have substantial population attributable risks. The identification of hypertension gene variants should provide new insight into the disease susceptibility, progression and severity. This will lead to the identification of potential targets for lifestyle and pharmacological interventions, with the ultimate goal of improving prevention, diagnosis and treatment.},
  author       = {Padmanabhan, Sandosh and Melander, Olle and Hastie, Claire and Menni, Cristina and Delles, Christian and Connell, John M and Dominiczak, Anna F},
  issn         = {1473-5598},
  language     = {eng},
  number       = {7},
  pages        = {1275--1281},
  publisher    = {ARRAY(0x85f9bc8)},
  series       = {Journal of Hypertension},
  title        = {Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e3282ff634f},
  volume       = {26},
  year         = {2008},
}