Effect on bone density of postoperative calcium and vitamin-D supplementation in patients with primary hyperparathyroidism: A retrospective study.
(2009) In Langenbeck's Archives of Surgery Jun 11. p.461-467- Abstract
- BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with decreased bone density and increased fracture risk. A significant number of pHPT patients have low calcium intake and suffer from vitamin deficiency. Thus, we adopted a policy of postoperative supplements with calcium and vitamin D after parathyroid surgery. In this study, we investigated if this policy enhanced the postoperative increase in bone density. PATIENTS/METHODS: Forty-two consecutive patients (83% female) were studied. The first 21 patients received no supplements, whereas the following 21 patients received 1,000 g calcium and 800 IU hydroxy D: -vitamin daily (Ca-D group) for 1 year postoperatively. The patients were monitored with bone density and biochemistry... (More)
- BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with decreased bone density and increased fracture risk. A significant number of pHPT patients have low calcium intake and suffer from vitamin deficiency. Thus, we adopted a policy of postoperative supplements with calcium and vitamin D after parathyroid surgery. In this study, we investigated if this policy enhanced the postoperative increase in bone density. PATIENTS/METHODS: Forty-two consecutive patients (83% female) were studied. The first 21 patients received no supplements, whereas the following 21 patients received 1,000 g calcium and 800 IU hydroxy D: -vitamin daily (Ca-D group) for 1 year postoperatively. The patients were monitored with bone density and biochemistry pre- and at 1 year postoperatively. RESULTS: Preoperatively, the patients without vitamin D supplementation (non-Ca-D group) did neither differ in biochemistry, clinical features, nor in bone density from patients in Ca-D group. Postoperatively, there was a tendency that patients in Ca-D group increased their bone density, at all sites measured, in a greater extent than patients that did not receive calcium and vitamin D supplementation. CONCLUSION: In conclusion, based on our results, it is difficult to give a recommendation of vitamin D supplementation in routine use following surgery for primary hyperparathyroidism. Based on the present data, a calculation of sample size for a future randomized controlled trial is presented. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1168910
- author
- Nordenström, Erik ; Westerdahl, Johan LU and Bergenfelz, Anders LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langenbeck's Archives of Surgery
- volume
- Jun 11
- pages
- 461 - 467
- publisher
- Springer
- external identifiers
-
- wos:000264486100008
- pmid:18546015
- scopus:67849133486
- pmid:18546015
- ISSN
- 1435-2451
- DOI
- 10.1007/s00423-008-0350-2
- language
- English
- LU publication?
- yes
- id
- af5d4120-9efc-4f67-89f3-3171c38ff5d2 (old id 1168910)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18546015?dopt=Abstract
- date added to LUP
- 2016-04-04 09:29:24
- date last changed
- 2022-04-23 20:50:32
@article{af5d4120-9efc-4f67-89f3-3171c38ff5d2,
abstract = {{BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with decreased bone density and increased fracture risk. A significant number of pHPT patients have low calcium intake and suffer from vitamin deficiency. Thus, we adopted a policy of postoperative supplements with calcium and vitamin D after parathyroid surgery. In this study, we investigated if this policy enhanced the postoperative increase in bone density. PATIENTS/METHODS: Forty-two consecutive patients (83% female) were studied. The first 21 patients received no supplements, whereas the following 21 patients received 1,000 g calcium and 800 IU hydroxy D: -vitamin daily (Ca-D group) for 1 year postoperatively. The patients were monitored with bone density and biochemistry pre- and at 1 year postoperatively. RESULTS: Preoperatively, the patients without vitamin D supplementation (non-Ca-D group) did neither differ in biochemistry, clinical features, nor in bone density from patients in Ca-D group. Postoperatively, there was a tendency that patients in Ca-D group increased their bone density, at all sites measured, in a greater extent than patients that did not receive calcium and vitamin D supplementation. CONCLUSION: In conclusion, based on our results, it is difficult to give a recommendation of vitamin D supplementation in routine use following surgery for primary hyperparathyroidism. Based on the present data, a calculation of sample size for a future randomized controlled trial is presented.}},
author = {{Nordenström, Erik and Westerdahl, Johan and Bergenfelz, Anders}},
issn = {{1435-2451}},
language = {{eng}},
pages = {{461--467}},
publisher = {{Springer}},
series = {{Langenbeck's Archives of Surgery}},
title = {{Effect on bone density of postoperative calcium and vitamin-D supplementation in patients with primary hyperparathyroidism: A retrospective study.}},
url = {{http://dx.doi.org/10.1007/s00423-008-0350-2}},
doi = {{10.1007/s00423-008-0350-2}},
volume = {{Jun 11}},
year = {{2009}},
}