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Effect on bone density of postoperative calcium and vitamin-D supplementation in patients with primary hyperparathyroidism: A retrospective study.

Nordenström, Erik; Westerdahl, Johan LU and Bergenfelz, Anders LU (2009) In Langenbeck's Archives of Surgery Jun 11. p.461-467
Abstract
BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with decreased bone density and increased fracture risk. A significant number of pHPT patients have low calcium intake and suffer from vitamin deficiency. Thus, we adopted a policy of postoperative supplements with calcium and vitamin D after parathyroid surgery. In this study, we investigated if this policy enhanced the postoperative increase in bone density. PATIENTS/METHODS: Forty-two consecutive patients (83% female) were studied. The first 21 patients received no supplements, whereas the following 21 patients received 1,000 g calcium and 800 IU hydroxy D: -vitamin daily (Ca-D group) for 1 year postoperatively. The patients were monitored with bone density and biochemistry... (More)
BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with decreased bone density and increased fracture risk. A significant number of pHPT patients have low calcium intake and suffer from vitamin deficiency. Thus, we adopted a policy of postoperative supplements with calcium and vitamin D after parathyroid surgery. In this study, we investigated if this policy enhanced the postoperative increase in bone density. PATIENTS/METHODS: Forty-two consecutive patients (83% female) were studied. The first 21 patients received no supplements, whereas the following 21 patients received 1,000 g calcium and 800 IU hydroxy D: -vitamin daily (Ca-D group) for 1 year postoperatively. The patients were monitored with bone density and biochemistry pre- and at 1 year postoperatively. RESULTS: Preoperatively, the patients without vitamin D supplementation (non-Ca-D group) did neither differ in biochemistry, clinical features, nor in bone density from patients in Ca-D group. Postoperatively, there was a tendency that patients in Ca-D group increased their bone density, at all sites measured, in a greater extent than patients that did not receive calcium and vitamin D supplementation. CONCLUSION: In conclusion, based on our results, it is difficult to give a recommendation of vitamin D supplementation in routine use following surgery for primary hyperparathyroidism. Based on the present data, a calculation of sample size for a future randomized controlled trial is presented. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langenbeck's Archives of Surgery
volume
Jun 11
pages
461 - 467
publisher
Springer
external identifiers
  • WOS:000264486100008
  • PMID:18546015
  • Scopus:67849133486
ISSN
1435-2451
DOI
10.1007/s00423-008-0350-2
language
English
LU publication?
yes
id
af5d4120-9efc-4f67-89f3-3171c38ff5d2 (old id 1168910)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18546015?dopt=Abstract
date added to LUP
2008-07-04 09:45:13
date last changed
2016-10-13 04:31:30
@misc{af5d4120-9efc-4f67-89f3-3171c38ff5d2,
  abstract     = {BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with decreased bone density and increased fracture risk. A significant number of pHPT patients have low calcium intake and suffer from vitamin deficiency. Thus, we adopted a policy of postoperative supplements with calcium and vitamin D after parathyroid surgery. In this study, we investigated if this policy enhanced the postoperative increase in bone density. PATIENTS/METHODS: Forty-two consecutive patients (83% female) were studied. The first 21 patients received no supplements, whereas the following 21 patients received 1,000 g calcium and 800 IU hydroxy D: -vitamin daily (Ca-D group) for 1 year postoperatively. The patients were monitored with bone density and biochemistry pre- and at 1 year postoperatively. RESULTS: Preoperatively, the patients without vitamin D supplementation (non-Ca-D group) did neither differ in biochemistry, clinical features, nor in bone density from patients in Ca-D group. Postoperatively, there was a tendency that patients in Ca-D group increased their bone density, at all sites measured, in a greater extent than patients that did not receive calcium and vitamin D supplementation. CONCLUSION: In conclusion, based on our results, it is difficult to give a recommendation of vitamin D supplementation in routine use following surgery for primary hyperparathyroidism. Based on the present data, a calculation of sample size for a future randomized controlled trial is presented.},
  author       = {Nordenström, Erik and Westerdahl, Johan and Bergenfelz, Anders},
  issn         = {1435-2451},
  language     = {eng},
  pages        = {461--467},
  publisher    = {ARRAY(0xb71c218)},
  series       = {Langenbeck's Archives of Surgery},
  title        = {Effect on bone density of postoperative calcium and vitamin-D supplementation in patients with primary hyperparathyroidism: A retrospective study.},
  url          = {http://dx.doi.org/10.1007/s00423-008-0350-2},
  volume       = {Jun 11},
  year         = {2009},
}