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Reproductive history, lifestyle factors and season as determinants for serum calcium concentrations in women.

Almquist, Martin LU ; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU ; Halthur, Cat; Malm, Johan LU and Manjer, Jonas LU (2008) In Scandinavian Journal of Clinical & Laboratory Investigation 68. p.777-785
Abstract
Objective. Serum calcium concentrations have been associated with the risk of malignant disease, especially breast cancer. Thus, determinants of serum calcium concentrations, with special regard to risk factors of breast cancer, are of great interest. Material and methods. Previous studies have either been small or they have not focused on reproductive factors. The present study examined serum calcium concentrations in relation to reproductive history, selected lifestyle factors and screening season in a large population-based cohort study comprising 8,114 women. ANOVA followed by the Bonferroni t-test were used for comparison of means, and logistic regression and multiple regression analysis were used to test associations. Results. Serum... (More)
Objective. Serum calcium concentrations have been associated with the risk of malignant disease, especially breast cancer. Thus, determinants of serum calcium concentrations, with special regard to risk factors of breast cancer, are of great interest. Material and methods. Previous studies have either been small or they have not focused on reproductive factors. The present study examined serum calcium concentrations in relation to reproductive history, selected lifestyle factors and screening season in a large population-based cohort study comprising 8,114 women. ANOVA followed by the Bonferroni t-test were used for comparison of means, and logistic regression and multiple regression analysis were used to test associations. Results. Serum calcium concentrations were lower in hormone replacement therapy users versus non-users (2.321 mmol/L versus 2.364; p<0.001) and in users of oral contraceptives versus non-users (2.304 versus 2.348; p<0.001). They were higher in peri-/postmenopausal versus premenopausal women (2.357 versus 2.319; p<0.001). Overweight and obese women had higher mean calcium concentrations (2.350 and 2.355) than women with body mass index between 20 and 25 (2.342; p<0.001). Serum calcium concentrations were higher in spring and autumn than in winter (2.352 and 2.353 versus 2.343; p = 0.002). Both younger (40-45 years) (2.334; p = 0.001) and older age groups (>55 years) (2.363; p<0.001) had higher mean calcium concentrations compared to those of women aged 45-50 years (2.320), even when adjusting for menopausal status, suggesting that age has an independent influence on calcium concentrations. Conclusions. It is concluded that reproductive factors such as menopausal status, use of oral contraceptives or hormone-replacement therapy, and age, BMI and season are associated with serum calcium concentrations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
68
pages
777 - 785
publisher
Informa Healthcare
external identifiers
  • WOS:000263221000017
  • PMID:18622803
  • Scopus:57349099909
ISSN
1502-7686
DOI
10.1080/00365510802262672
language
English
LU publication?
yes
id
7e772894-a9eb-4adc-96ba-51dc2f5ae3c5 (old id 1181232)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18622803?dopt=Abstract
date added to LUP
2008-08-08 14:48:56
date last changed
2016-10-13 04:31:52
@misc{7e772894-a9eb-4adc-96ba-51dc2f5ae3c5,
  abstract     = {Objective. Serum calcium concentrations have been associated with the risk of malignant disease, especially breast cancer. Thus, determinants of serum calcium concentrations, with special regard to risk factors of breast cancer, are of great interest. Material and methods. Previous studies have either been small or they have not focused on reproductive factors. The present study examined serum calcium concentrations in relation to reproductive history, selected lifestyle factors and screening season in a large population-based cohort study comprising 8,114 women. ANOVA followed by the Bonferroni t-test were used for comparison of means, and logistic regression and multiple regression analysis were used to test associations. Results. Serum calcium concentrations were lower in hormone replacement therapy users versus non-users (2.321 mmol/L versus 2.364; p&lt;0.001) and in users of oral contraceptives versus non-users (2.304 versus 2.348; p&lt;0.001). They were higher in peri-/postmenopausal versus premenopausal women (2.357 versus 2.319; p&lt;0.001). Overweight and obese women had higher mean calcium concentrations (2.350 and 2.355) than women with body mass index between 20 and 25 (2.342; p&lt;0.001). Serum calcium concentrations were higher in spring and autumn than in winter (2.352 and 2.353 versus 2.343; p = 0.002). Both younger (40-45 years) (2.334; p = 0.001) and older age groups (&gt;55 years) (2.363; p&lt;0.001) had higher mean calcium concentrations compared to those of women aged 45-50 years (2.320), even when adjusting for menopausal status, suggesting that age has an independent influence on calcium concentrations. Conclusions. It is concluded that reproductive factors such as menopausal status, use of oral contraceptives or hormone-replacement therapy, and age, BMI and season are associated with serum calcium concentrations.},
  author       = {Almquist, Martin and Bondeson, Anne-Greth and Bondeson, Lennart and Halthur, Cat and Malm, Johan and Manjer, Jonas},
  issn         = {1502-7686},
  language     = {eng},
  pages        = {777--785},
  publisher    = {ARRAY(0xbf18df8)},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Reproductive history, lifestyle factors and season as determinants for serum calcium concentrations in women.},
  url          = {http://dx.doi.org/10.1080/00365510802262672},
  volume       = {68},
  year         = {2008},
}