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Recurrent and multiple bladder tumors show conserved expression profiles.

Lindgren, David LU ; Gudjonsson, Sigurdur LU ; Jee, Kowan Ja; Liedberg, Fredrik LU ; Aits, Sonja LU ; Andersson, Anna LU ; Chebil, Gunilla; Borg, Åke LU ; Knuutila, Sakari and Fioretos, Thoas LU , et al. (2008) In BMC Cancer 8(June 30).
Abstract
BACKGROUND: Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recurrences after treatment making follow-up necessary. The leading hypothesis explaining the origin of meta- and synchronous tumors assumes a monoclonal origin. However, the genetic relationship among consecutive tumors has been shown to be complex in as much as the genetic evolution does not adhere to the chronological appearance of the metachronous tumors. Consequently, genetically less evolved tumors may appear chronologically later than genetically related but more evolved tumors. METHODS: Forty-nine meta- or synchronous... (More)
BACKGROUND: Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recurrences after treatment making follow-up necessary. The leading hypothesis explaining the origin of meta- and synchronous tumors assumes a monoclonal origin. However, the genetic relationship among consecutive tumors has been shown to be complex in as much as the genetic evolution does not adhere to the chronological appearance of the metachronous tumors. Consequently, genetically less evolved tumors may appear chronologically later than genetically related but more evolved tumors. METHODS: Forty-nine meta- or synchronous urothelial tumors from 22 patients were analyzed using expression profiling, conventional CGH, LOH, and mutation analyses. RESULTS: We show by CGH that partial chromosomal losses in the initial tumors may not be present in the recurring tumors, by LOH that different haplotypes may be lost and that detected regions of LOH may be smaller in recurring tumors, and that mutations present in the initial tumor may not be present in the recurring ones. In contrast we show that despite apparent genomic differences, the recurrent and multiple bladder tumors from the same patients display remarkably similar expression profiles. CONCLUSION: Our findings show that even though the vast majority of the analyzed meta- and synchronous tumors from the same patients are not likely to have originated directly from the preceding tumor they still show remarkably similar expressions profiles. The presented data suggests that an expression profile is established early in tumor development and that this profile is stable and maintained in recurring tumors. (Less)
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Contribution to journal
publication status
published
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BMC Cancer
volume
8
issue
June 30
publisher
BioMed Central
external identifiers
  • WOS:000258100600001
  • PMID:18590527
  • Scopus:48549105755
ISSN
1471-2407
DOI
10.1186/1471-2407-8-183
language
English
LU publication?
yes
id
519bf83e-c2c7-4019-8e7e-ca510e2fe8f1 (old id 1181726)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18590527?dopt=Abstract
date added to LUP
2008-08-06 10:44:56
date last changed
2016-10-13 04:31:09
@misc{519bf83e-c2c7-4019-8e7e-ca510e2fe8f1,
  abstract     = {BACKGROUND: Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recurrences after treatment making follow-up necessary. The leading hypothesis explaining the origin of meta- and synchronous tumors assumes a monoclonal origin. However, the genetic relationship among consecutive tumors has been shown to be complex in as much as the genetic evolution does not adhere to the chronological appearance of the metachronous tumors. Consequently, genetically less evolved tumors may appear chronologically later than genetically related but more evolved tumors. METHODS: Forty-nine meta- or synchronous urothelial tumors from 22 patients were analyzed using expression profiling, conventional CGH, LOH, and mutation analyses. RESULTS: We show by CGH that partial chromosomal losses in the initial tumors may not be present in the recurring tumors, by LOH that different haplotypes may be lost and that detected regions of LOH may be smaller in recurring tumors, and that mutations present in the initial tumor may not be present in the recurring ones. In contrast we show that despite apparent genomic differences, the recurrent and multiple bladder tumors from the same patients display remarkably similar expression profiles. CONCLUSION: Our findings show that even though the vast majority of the analyzed meta- and synchronous tumors from the same patients are not likely to have originated directly from the preceding tumor they still show remarkably similar expressions profiles. The presented data suggests that an expression profile is established early in tumor development and that this profile is stable and maintained in recurring tumors.},
  author       = {Lindgren, David and Gudjonsson, Sigurdur and Jee, Kowan Ja and Liedberg, Fredrik and Aits, Sonja and Andersson, Anna and Chebil, Gunilla and Borg, Åke and Knuutila, Sakari and Fioretos, Thoas and Månsson, Wiking and Höglund, Mattias},
  issn         = {1471-2407},
  language     = {eng},
  number       = {June 30},
  publisher    = {ARRAY(0xa7950b0)},
  series       = {BMC Cancer},
  title        = {Recurrent and multiple bladder tumors show conserved expression profiles.},
  url          = {http://dx.doi.org/10.1186/1471-2407-8-183},
  volume       = {8},
  year         = {2008},
}