Advanced

Induction of platelet thrombi by bacteria and antibodies.

Sjöbring, Ulf LU ; Ringdahl, Ulrika LU and Ruggieri, ZM (2002) In Blood 100(13). p.4470-4477
Abstract
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies against the bacteria, immunoglobulin (Ig) G may cluster on the same surface and activate adherent platelets through the Fc(gamma)RIIA receptor, leading to thrombus growth. As an alternative, bacteria that cannot bind fibrinogen may attach to substrates, such as immobilized plasma proteins or components of the extracellular matrix, which also support... (More)
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies against the bacteria, immunoglobulin (Ig) G may cluster on the same surface and activate adherent platelets through the Fc(gamma)RIIA receptor, leading to thrombus growth. As an alternative, bacteria that cannot bind fibrinogen may attach to substrates, such as immobilized plasma proteins or components of the extracellular matrix, which also support platelet adhesion. As a result of this colocalization, IgG bound to bacteria can activate neighboring platelets and induce thrombus growth regardless of their ability to initiate platelet-surface contact. Our results demonstrate that intrinsic constituents of infectious agents and host proteins play distinct but complementary roles in recruiting platelets into thrombi, possibly contributing to complications of acute and chronic infections (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
100
issue
13
pages
4470 - 4477
publisher
American Society of Hematology
external identifiers
  • Other:10.1182
  • Scopus:0037114630
ISSN
1528-0020
language
English
LU publication?
yes
id
29ffb47d-3b9b-422d-a584-8885a441ba5e (old id 1216523)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/12393652
http://bloodjournal.hematologylibrary.org/content/100/13/4470.long
date added to LUP
2013-10-09 15:52:14
date last changed
2016-12-04 04:48:13
@misc{29ffb47d-3b9b-422d-a584-8885a441ba5e,
  abstract     = {We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies against the bacteria, immunoglobulin (Ig) G may cluster on the same surface and activate adherent platelets through the Fc(gamma)RIIA receptor, leading to thrombus growth. As an alternative, bacteria that cannot bind fibrinogen may attach to substrates, such as immobilized plasma proteins or components of the extracellular matrix, which also support platelet adhesion. As a result of this colocalization, IgG bound to bacteria can activate neighboring platelets and induce thrombus growth regardless of their ability to initiate platelet-surface contact. Our results demonstrate that intrinsic constituents of infectious agents and host proteins play distinct but complementary roles in recruiting platelets into thrombi, possibly contributing to complications of acute and chronic infections},
  author       = {Sjöbring, Ulf and Ringdahl, Ulrika and Ruggieri, ZM},
  issn         = {1528-0020},
  language     = {eng},
  number       = {13},
  pages        = {4470--4477},
  publisher    = {ARRAY(0x8490840)},
  series       = {Blood},
  title        = {Induction of platelet thrombi by bacteria and antibodies.},
  volume       = {100},
  year         = {2002},
}