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The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.

Edström, Anneli M L; Malm, Johan LU ; Frohm, Birgitta LU ; Martellini, Julie A; Giwercman, Aleksander LU ; Mörgelin, Matthias LU ; Cole, Alexander M and Sørensen, Ole E (2008) In Journal of immunology (Baltimore, Md. : 1950) 181(5). p.3413-3421
Abstract
One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of the semenogelins while the semenogelin holoproteins displayed no antibacterial activity. After ejaculation the semenogelin-derived peptides were fragmented to smaller and smaller fragments over time and thereby lost antibacterial activity. This paralleled the loss of antibacterial activity of whole seminal plasma both in vitro and after sexual... (More)
One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of the semenogelins while the semenogelin holoproteins displayed no antibacterial activity. After ejaculation the semenogelin-derived peptides were fragmented to smaller and smaller fragments over time and thereby lost antibacterial activity. This paralleled the loss of antibacterial activity of whole seminal plasma both in vitro and after sexual intercourse. Moreover, the antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH. These data provide novel roles for the resolution of seminal clots and for the high zinc concentration in human seminal plasma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of immunology (Baltimore, Md. : 1950)
volume
181
issue
5
pages
3413 - 3421
publisher
American Association of Immunologists
external identifiers
  • WOS:000259511800051
  • PMID:18714013
  • Scopus:51549086806
ISSN
1550-6606
language
English
LU publication?
yes
id
a9d98893-a471-41a2-b834-6b724beb339e (old id 1223053)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18714013?dopt=Abstract
date added to LUP
2008-09-03 13:06:48
date last changed
2016-11-01 10:16:42
@misc{a9d98893-a471-41a2-b834-6b724beb339e,
  abstract     = {One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of the semenogelins while the semenogelin holoproteins displayed no antibacterial activity. After ejaculation the semenogelin-derived peptides were fragmented to smaller and smaller fragments over time and thereby lost antibacterial activity. This paralleled the loss of antibacterial activity of whole seminal plasma both in vitro and after sexual intercourse. Moreover, the antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH. These data provide novel roles for the resolution of seminal clots and for the high zinc concentration in human seminal plasma.},
  author       = {Edström, Anneli M L and Malm, Johan and Frohm, Birgitta and Martellini, Julie A and Giwercman, Aleksander and Mörgelin, Matthias and Cole, Alexander M and Sørensen, Ole E},
  issn         = {1550-6606},
  language     = {eng},
  number       = {5},
  pages        = {3413--3421},
  publisher    = {ARRAY(0xb90b188)},
  series       = {Journal of immunology (Baltimore, Md. : 1950)},
  title        = {The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.},
  volume       = {181},
  year         = {2008},
}