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Lung function in relation to 2-thiothiazolidine-4-carboxylic Acid and genetic effect modification among rubber workers in sweden.

Jönsson, Lena S LU ; Littorin, Margareta LU ; Axmon, Anna LU ; Jönsson, Bo A LU and Broberg Palmgren, Karin LU (2008) In Journal of Occupational and Environmental Medicine 50(9). p.1006-1012
Abstract
OBJECTIVE:: What is the risk of impaired lung function in contemporary Swedish rubber workers and are there modifying effects of genetic variants? METHODS:: Included in the study were 159 rubber exposed and 118 not-rubber exposed workers. Lung function was analyzed as forced vital capacity percent of predicted and forced expiratory volume in 1 second percent of predicted. Levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) was assessed with liquid chromatography tandem mass spectrometry. Polymorphisms in glutathione-related genes were analyzed by Taqman-based allelic discrimination and ordinary polymerase chain reaction. RESULTS:: There was an association between increasing levels of... (More)
OBJECTIVE:: What is the risk of impaired lung function in contemporary Swedish rubber workers and are there modifying effects of genetic variants? METHODS:: Included in the study were 159 rubber exposed and 118 not-rubber exposed workers. Lung function was analyzed as forced vital capacity percent of predicted and forced expiratory volume in 1 second percent of predicted. Levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) was assessed with liquid chromatography tandem mass spectrometry. Polymorphisms in glutathione-related genes were analyzed by Taqman-based allelic discrimination and ordinary polymerase chain reaction. RESULTS:: There was an association between increasing levels of 2-thiothiazolidine-4-carboxylic acid and impaired lung function among exposed workers. The association was modified by glutathione S-transferase alpha 1 (GSTA1)-52 and GSTP1-114. GSTM1 had an influence on lung function among unexposed workers. CONCLUSIONS:: There may be a risk of impaired lung function in contemporary rubber workers. Gene-modifying effects may be considered in risk assessments. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Occupational and Environmental Medicine
volume
50
issue
9
pages
1006 - 1012
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000259325900004
  • PMID:18784548
  • Scopus:62649105327
ISSN
1536-5948
DOI
10.1097/JOM.0b013e3181715126
language
English
LU publication?
yes
id
50645a6a-f0d3-427f-94a4-907e2542a3e3 (old id 1243138)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18784548?dopt=Abstract
date added to LUP
2008-10-07 13:47:19
date last changed
2016-10-13 04:29:49
@misc{50645a6a-f0d3-427f-94a4-907e2542a3e3,
  abstract     = {OBJECTIVE:: What is the risk of impaired lung function in contemporary Swedish rubber workers and are there modifying effects of genetic variants? METHODS:: Included in the study were 159 rubber exposed and 118 not-rubber exposed workers. Lung function was analyzed as forced vital capacity percent of predicted and forced expiratory volume in 1 second percent of predicted. Levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) was assessed with liquid chromatography tandem mass spectrometry. Polymorphisms in glutathione-related genes were analyzed by Taqman-based allelic discrimination and ordinary polymerase chain reaction. RESULTS:: There was an association between increasing levels of 2-thiothiazolidine-4-carboxylic acid and impaired lung function among exposed workers. The association was modified by glutathione S-transferase alpha 1 (GSTA1)-52 and GSTP1-114. GSTM1 had an influence on lung function among unexposed workers. CONCLUSIONS:: There may be a risk of impaired lung function in contemporary rubber workers. Gene-modifying effects may be considered in risk assessments.},
  author       = {Jönsson, Lena S and Littorin, Margareta and Axmon, Anna and Jönsson, Bo A and Broberg Palmgren, Karin},
  issn         = {1536-5948},
  language     = {eng},
  number       = {9},
  pages        = {1006--1012},
  publisher    = {ARRAY(0x8cd9868)},
  series       = {Journal of Occupational and Environmental Medicine},
  title        = {Lung function in relation to 2-thiothiazolidine-4-carboxylic Acid and genetic effect modification among rubber workers in sweden.},
  url          = {http://dx.doi.org/10.1097/JOM.0b013e3181715126},
  volume       = {50},
  year         = {2008},
}