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Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias.

Carta, Manolo LU ; Carlsson, Thomas LU ; Munoz, Ana LU ; Kirik, Deniz LU and Björklund, Anders LU (2008) In Progress in Brain Research 172. p.465-478
Abstract
Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Progress in Brain Research
volume
172
pages
465 - 478
publisher
Elsevier
external identifiers
  • WOS:000280603200023
  • PMID:18772046
  • Scopus:50349084288
ISSN
1875-7855
DOI
10.1016/S0079-6123(08)00922-9
language
English
LU publication?
yes
id
0304601e-3652-43d5-ab6e-6c40e534c4ed (old id 1243349)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18772046?dopt=Abstract
date added to LUP
2008-10-06 11:56:28
date last changed
2016-10-30 04:35:23
@misc{0304601e-3652-43d5-ab6e-6c40e534c4ed,
  abstract     = {Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication.},
  author       = {Carta, Manolo and Carlsson, Thomas and Munoz, Ana and Kirik, Deniz and Björklund, Anders},
  issn         = {1875-7855},
  language     = {eng},
  pages        = {465--478},
  publisher    = {ARRAY(0x9188d70)},
  series       = {Progress in Brain Research},
  title        = {Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias.},
  url          = {http://dx.doi.org/10.1016/S0079-6123(08)00922-9},
  volume       = {172},
  year         = {2008},
}