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Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.

Lindehammer, Sabina LU ; Larsson, Karin LU ; Ortqvist, E; Carlsson, A; Cederwall, E; Cilio, Corrado LU ; Ivarsson, S-A; Jönsson, B; Larsson, Helena LU and Lynch, Kristian LU , et al. (2008) In Acta Diabetologica Sep 4. p.231-235
Abstract
The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P < 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in... (More)
The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P < 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Diabetologica
volume
Sep 4
pages
231 - 235
publisher
Springer
external identifiers
  • WOS:000260538200006
  • PMID:18769865
  • Scopus:55949118394
ISSN
1432-5233
DOI
10.1007/s00592-008-0048-5
language
English
LU publication?
yes
id
446a7cab-da22-47d7-8a99-cb71dcbeb315 (old id 1243373)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18769865?dopt=Abstract
date added to LUP
2008-10-03 16:05:19
date last changed
2016-10-13 04:32:57
@misc{446a7cab-da22-47d7-8a99-cb71dcbeb315,
  abstract     = {The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P &lt; 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P &gt; 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.},
  author       = {Lindehammer, Sabina and Larsson, Karin and Ortqvist, E and Carlsson, A and Cederwall, E and Cilio, Corrado and Ivarsson, S-A and Jönsson, B and Larsson, Helena and Lynch, Kristian and Neiderud, J and Nilsson, Anna and Sjöblad, Sture and Lernmark, Åke},
  issn         = {1432-5233},
  language     = {eng},
  pages        = {231--235},
  publisher    = {ARRAY(0x8b68750)},
  series       = {Acta Diabetologica},
  title        = {Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.},
  url          = {http://dx.doi.org/10.1007/s00592-008-0048-5},
  volume       = {Sep 4},
  year         = {2008},
}