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Nontypeable Haemophilus influenzae as a Pathogen in Children.

Murphy, Timothy; Faden, Howard; Bakaletz, Lauren; Kyd, Jennelle; Forsgren, Arne LU ; Campos, José LU ; Virji, Mumtaz and Pelton, Stephen (2009) In Pediatric Infectious Disease Journal 28(1). p.43-48
Abstract
Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H. influenzae type b conjugate vaccines have no effect on infections caused by nontypeable strains because nontypeable strains are nonencapsulated. Approximately, one-third of episodes of otitis media are caused by nontypeable H. influenzae and the bacterium is the most common cause of recurrent otitis media. Recent progress in elucidating molecular mechanisms of pathogenesis, understanding the role of biofilms in otitis media and an increasing understanding of immune responses have potential for development of novel strategies to improve prevention and treatment of... (More)
Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H. influenzae type b conjugate vaccines have no effect on infections caused by nontypeable strains because nontypeable strains are nonencapsulated. Approximately, one-third of episodes of otitis media are caused by nontypeable H. influenzae and the bacterium is the most common cause of recurrent otitis media. Recent progress in elucidating molecular mechanisms of pathogenesis, understanding the role of biofilms in otitis media and an increasing understanding of immune responses have potential for development of novel strategies to improve prevention and treatment of otitis media caused by nontypeable H. influenzae. Feasibility of vaccination for prevention of otitis media due to nontypeable H. influenzae was recently demonstrated in a clinical trial with a vaccine that included the surface virulence factor, protein D. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Infectious Disease Journal
volume
28
issue
1
pages
43 - 48
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000262247200011
  • PMID:19057458
  • Scopus:65649084792
ISSN
1532-0987
DOI
10.1097/INF.0b013e318184dba2
language
English
LU publication?
yes
id
31c02d38-b942-4947-9fdb-79d3bef48efb (old id 1276418)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19057458?dopt=Abstract
date added to LUP
2009-01-09 09:00:10
date last changed
2016-11-06 04:25:39
@misc{31c02d38-b942-4947-9fdb-79d3bef48efb,
  abstract     = {Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H. influenzae type b conjugate vaccines have no effect on infections caused by nontypeable strains because nontypeable strains are nonencapsulated. Approximately, one-third of episodes of otitis media are caused by nontypeable H. influenzae and the bacterium is the most common cause of recurrent otitis media. Recent progress in elucidating molecular mechanisms of pathogenesis, understanding the role of biofilms in otitis media and an increasing understanding of immune responses have potential for development of novel strategies to improve prevention and treatment of otitis media caused by nontypeable H. influenzae. Feasibility of vaccination for prevention of otitis media due to nontypeable H. influenzae was recently demonstrated in a clinical trial with a vaccine that included the surface virulence factor, protein D.},
  author       = {Murphy, Timothy and Faden, Howard and Bakaletz, Lauren and Kyd, Jennelle and Forsgren, Arne and Campos, José and Virji, Mumtaz and Pelton, Stephen},
  issn         = {1532-0987},
  language     = {eng},
  number       = {1},
  pages        = {43--48},
  publisher    = {ARRAY(0xaaf28a8)},
  series       = {Pediatric Infectious Disease Journal},
  title        = {Nontypeable Haemophilus influenzae as a Pathogen in Children.},
  url          = {http://dx.doi.org/10.1097/INF.0b013e318184dba2},
  volume       = {28},
  year         = {2009},
}