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Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction.

Diab, Kerstin LU ; Truedsson, Lennart LU ; Albin, Maria LU and Nielsen, Jörn LU (2009) In International Archives of Occupational and Environmental Health 82. p.771-777
Abstract
PURPOSE: The aim of this study was to examine the effects of persulphate on the nasal mucosa and on the immune cells in hairdressers suffering from bleaching powder associated rhinitis (BAR) versus subjects with rhinitis not previously exposed to bleaching powder. METHODS: Fifteen hairdressers (S) with BAR, 14 without symptoms (WS) and 12 atopics (A) with rhinitis but without exposure to bleaching powder were studied. Each performed a nasal challenge with persulphates. Effect parameters were symptom score, acoustic rhinometry, albumin in nasal lavage, subpopulations of lymphocytes in blood and specific serum antibodies. RESULTS: The S group had a post-challenge increase in nasal symptoms and nasal lavage albumin. The A group reacted to a... (More)
PURPOSE: The aim of this study was to examine the effects of persulphate on the nasal mucosa and on the immune cells in hairdressers suffering from bleaching powder associated rhinitis (BAR) versus subjects with rhinitis not previously exposed to bleaching powder. METHODS: Fifteen hairdressers (S) with BAR, 14 without symptoms (WS) and 12 atopics (A) with rhinitis but without exposure to bleaching powder were studied. Each performed a nasal challenge with persulphates. Effect parameters were symptom score, acoustic rhinometry, albumin in nasal lavage, subpopulations of lymphocytes in blood and specific serum antibodies. RESULTS: The S group had a post-challenge increase in nasal symptoms and nasal lavage albumin. The A group reacted to a lesser intent. The S and A groups showed an increase in Th1 cells. An HLA class II cell expression was noticed in both groups of hairdressers. No evidence of a type 1 reaction (immediate type) to persulphate was noticed. CONCLUSIONS: Persulphate challenge affects hairdressers with BAR, but also atopics. The reaction may be driven by a Th1 cell activation. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Archives of Occupational and Environmental Health
volume
82
pages
771 - 777
publisher
Springer
external identifiers
  • WOS:000265686100009
  • PMID:19048274
  • Scopus:67349195996
ISSN
1432-1246
DOI
10.1007/s00420-008-0392-3
language
English
LU publication?
yes
id
d5a251bf-73ef-46db-8a6c-fbe4bf30e44c (old id 1276602)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19048274?dopt=Abstract
date added to LUP
2009-01-09 08:28:57
date last changed
2016-10-13 04:30:31
@misc{d5a251bf-73ef-46db-8a6c-fbe4bf30e44c,
  abstract     = {PURPOSE: The aim of this study was to examine the effects of persulphate on the nasal mucosa and on the immune cells in hairdressers suffering from bleaching powder associated rhinitis (BAR) versus subjects with rhinitis not previously exposed to bleaching powder. METHODS: Fifteen hairdressers (S) with BAR, 14 without symptoms (WS) and 12 atopics (A) with rhinitis but without exposure to bleaching powder were studied. Each performed a nasal challenge with persulphates. Effect parameters were symptom score, acoustic rhinometry, albumin in nasal lavage, subpopulations of lymphocytes in blood and specific serum antibodies. RESULTS: The S group had a post-challenge increase in nasal symptoms and nasal lavage albumin. The A group reacted to a lesser intent. The S and A groups showed an increase in Th1 cells. An HLA class II cell expression was noticed in both groups of hairdressers. No evidence of a type 1 reaction (immediate type) to persulphate was noticed. CONCLUSIONS: Persulphate challenge affects hairdressers with BAR, but also atopics. The reaction may be driven by a Th1 cell activation.},
  author       = {Diab, Kerstin and Truedsson, Lennart and Albin, Maria and Nielsen, Jörn},
  issn         = {1432-1246},
  language     = {eng},
  pages        = {771--777},
  publisher    = {ARRAY(0xdf8bc88)},
  series       = {International Archives of Occupational and Environmental Health},
  title        = {Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction.},
  url          = {http://dx.doi.org/10.1007/s00420-008-0392-3},
  volume       = {82},
  year         = {2009},
}